Emerging trends in Optofluidic biosensing: Techniques, applications, and future directions

IF 10.61 Q3 Biochemistry, Genetics and Molecular Biology Biosensors and Bioelectronics: X Pub Date : 2025-03-13 DOI:10.1016/j.biosx.2025.100602

Renu Poria , Sahil Kumar , Deepak Kala , Maciej Sakowicz , Hardeep Tuli , Krishna Kattel , Ankur Kaushal , Shagun Gupta , Deepak Kumar

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Abstract

This review explores the potential of optofluidic biosensing platforms, emphasizing their application in enhancing biosensing capabilities. This paper reports the various platforms, starting with surface plasmon resonance (SPR)-based optofluidic biosensors, covering angular and spectral SPR biosensing, local SPR biosensing, and the sensitivity and limit of detection (LOD) of both propagating and localized SPR, including multiplexing SPR biosensing techniques. This review further examines whispering gallery mode (WGM) microcavity-based biosensors and photonic crystal-based optofluidic biosensors. A comprehensive overview of the fabrication techniques for optofluidic biosensors is provided, detailing strategies such as direct manufacturing and mold replication. Key components such as fluid control, light manipulation, and signal transduction are highlighted. The material choices for optofluidics are discussed, emphasizing their role in biosensing applications. This paper concludes by exploring optofluidic sensing applications, categorized into absorption-based, plasmonic-based, and scattering-based biosensing techniques. Recent advancements and future directions in the field are discussed, highlighting the integration of these technologies into portable, multiplexed platforms for broader application and ease of use in various scientific and practical fields.

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来源期刊

Biosensors and Bioelectronics: X Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

4.60

自引率

0.00%

发文量

166

审稿时长

54 days

期刊介绍： Biosensors and Bioelectronics: X, an open-access companion journal of Biosensors and Bioelectronics, boasts a 2020 Impact Factor of 10.61 (Journal Citation Reports, Clarivate Analytics 2021). Offering authors the opportunity to share their innovative work freely and globally, Biosensors and Bioelectronics: X aims to be a timely and permanent source of information. The journal publishes original research papers, review articles, communications, editorial highlights, perspectives, opinions, and commentaries at the intersection of technological advancements and high-impact applications. Manuscripts submitted to Biosensors and Bioelectronics: X are assessed based on originality and innovation in technology development or applications, aligning with the journal's goal to cater to a broad audience interested in this dynamic field.