Newly Developed Calcium-Enriched Hemostatic Sponge Enhanced Wound Healing and Regeneration

Abstract

This study focuses on the development, characterization, and validation of a carbonate apatite (CHA)-enriched hemostatic sponge and the evaluation of its ability to enhance wound healing and regeneration through the controlled release of calcium ions (Ca²⁺). CHA, a bioactive material resembling the natural apatite in human bone, was synthesized within gelatin matrices to form a composite sponge. The synthesis incorporated β-type carbonate ion substitutions in the CHA structure, enabling dynamic dissolution and the gradual release of Ca²⁺ ions at the site of injury. This targeted release was shown to accelerate wound healing and tissue regeneration without causing irritation. The presence of calcium ions in the CHA composite was identified as a critical factor in supporting hemostatic processes, emphasizing their importance in wound care. The CHA-enriched hemostatic sponge demonstrated superior healing outcomes, positioning it as a promising next-generation biomedical device for hemostatic purposes and wound regeneration applications. Moreover, the CHA structure offers potential for surface modifications to introduce additional functionalities, such as inherent antimicrobial properties, further enhancing its biological performance and expanding its applications in advanced wound care.