The relationship between advanced glycation end products, metabolic metrics, HbA_1c, and diabetic nephropathy.

IF 4.6 2区医学 Q2 ENDOCRINOLOGY & METABOLISM Frontiers in Endocrinology Pub Date : 2025-03-07 eCollection Date: 2025-01-01 DOI:10.3389/fendo.2025.1468737

Liping Xue, Yi Zhang, Qiu Zhang

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Abstract

Background: In this cross-sectional study, we aim to investigate the value of non-invasive advanced glycation end products (AGEs) detection in the early screening of diabetic nephropathy(DN) among individuals with type 2 diabetes mellitus and assess whether metabolic parameters and glycated hemoglobin A_1c (HbA_1c) can moderate this relationship.

Methods: A total of 912 T2DM patients were enrolled. The urinary albumin-to-creatinine ratio (UACR) was measured in morning urine samples to assess DN. AGEs were non-invasively measured through skin autofluorescence. Recognizing the role of age in both AGEs and DN, AGE_age was calculated as AGEs × age/100 for related analyses.

Results: The overall prevalence of DN in the present study was 37.2%. Elevated AGE_age(χ² = 61.06) was associated with a higher prevalence of DN. Multivariable linear regression demonstrated that AGE_age was positively associated with UACR levels(β = 0.154, 95% CI: 0.126, 0.306, P<0.001). In the moderation analysis, glycated hemoglobin A_1c (HbA_1c) affected the correlation between AGE_age and UACR. Body mass index (BMI) and triglyceride glucose-body mass index (TyG-BMI) also affect the correlation between AGE_age and UACR, there were significant interactions between AGE_age, HbA_1c, BMI, TyG-BMI, and UACR.

Conclusions: Complex associations and interactions were observed between AGEs, metabolic metrics, HbA_1c, and DN. Implementing comprehensive interventions can potentially benefit the prevention of DN in T2DM patients.

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高级糖化终末产物、代谢指标、HbA1c 和糖尿病肾病之间的关系。

背景：在这项横断面研究中，我们旨在探讨无创晚期糖基化终产物（AGEs）检测在2型糖尿病患者糖尿病肾病（DN）早期筛查中的价值，并评估代谢参数和糖化血红蛋白A1c （HbA1c）是否可以调节这种关系。方法：共纳入912例T2DM患者。测定晨尿白蛋白与肌酐比值（UACR）以评估DN。通过皮肤自身荧光无创测量AGEs。考虑到年龄在AGEs和DN中的作用，AGEage计算为AGEs × age/100进行相关分析。结果：本组DN总患病率为37.2%。年龄升高与DN患病率升高相关（χ2 = 61.06）。多变量线性回归表明，年龄与UACR水平呈正相关（β = 0.154, 95% CI: 0.126, 0.306）， P1c （HbA1c）影响年龄与UACR的相关性。体重指数（BMI）和甘油三酯-葡萄糖-体重指数（TyG-BMI）也影响年龄与UACR的相关性，年龄、HbA1c、BMI、TyG-BMI和UACR之间存在显著的交互作用。结论：在AGEs、代谢指标、HbA1c和DN之间观察到复杂的关联和相互作用。实施综合干预可能有利于预防2型糖尿病患者的DN。

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来源期刊

Frontiers in Endocrinology Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

5.70

自引率

9.60%

发文量

3023

审稿时长

14 weeks

期刊介绍： Frontiers in Endocrinology is a field journal of the "Frontiers in" journal series. In today’s world, endocrinology is becoming increasingly important as it underlies many of the challenges societies face - from obesity and diabetes to reproduction, population control and aging. Endocrinology covers a broad field from basic molecular and cellular communication through to clinical care and some of the most crucial public health issues. The journal, thus, welcomes outstanding contributions in any domain of endocrinology. Frontiers in Endocrinology publishes articles on the most outstanding discoveries across a wide research spectrum of Endocrinology. The mission of Frontiers in Endocrinology is to bring all relevant Endocrinology areas together on a single platform.