{"title":"Baicalein: unveiling the multifaceted marvel of hepatoprotection and beyond","authors":"Ashish Dogra","doi":"10.1080/10286020.2025.2481273","DOIUrl":null,"url":null,"abstract":"<div><div>Flavonoids are bioactive compounds derived from plants that play a crucial role in human health. Baicalein is a prominent phytoconstituent with multifaceted therapeutic potential against various diseases. This review explores recent advancements in understanding baicalein’s hepatoprotective action against different toxicity models (acetaminophen, cisplatin, doxorubicin, CCL<sub>4</sub>, monocrotaline, & d-galactosamine). Furthermore, we report the key pharmacological activities of baicalein against neurotoxicity (6-OHDA, rotenone, d-galactose, stroke, alzheimer, & sclerosis), inflammation (arthritis, pulmonary fibrosis, & LPS-induced sepsis), cancer (breast, prostate, gall bladder, gastric, & pancreatic), & diabetes. Overall, baicalein has potential to influence diverse biological networks, making it a promising candidate for both dietary supplementation and therapeutic development.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 9","pages":"Pages 1223-1235"},"PeriodicalIF":1.3000,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Asian Natural Products Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1028602025000384","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/21 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Flavonoids are bioactive compounds derived from plants that play a crucial role in human health. Baicalein is a prominent phytoconstituent with multifaceted therapeutic potential against various diseases. This review explores recent advancements in understanding baicalein’s hepatoprotective action against different toxicity models (acetaminophen, cisplatin, doxorubicin, CCL4, monocrotaline, & d-galactosamine). Furthermore, we report the key pharmacological activities of baicalein against neurotoxicity (6-OHDA, rotenone, d-galactose, stroke, alzheimer, & sclerosis), inflammation (arthritis, pulmonary fibrosis, & LPS-induced sepsis), cancer (breast, prostate, gall bladder, gastric, & pancreatic), & diabetes. Overall, baicalein has potential to influence diverse biological networks, making it a promising candidate for both dietary supplementation and therapeutic development.
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
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