CXCR4 expression in immunohistochemistry of gastrointestinal neuroendocrine neoplasms: a meta-analysis.

Q2 Health Professions Journal of immunoassay & immunochemistry Pub Date : 2025-01-01 Epub Date: 2025-03-24 DOI:10.1080/15321819.2025.2482642

Changlong Ruan, Jiajia Zhang, Yingying Liao, Yujie Hang, Yuan Dong, Hanfeng Shi, Xiaoya Wang

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Abstract

Objective: C-X-C chemokine receptor type 4 (CXCR4) is significantly associated with the development of various malignant tumors. This meta-analysis aims to investigate the expression of CXCR4 in the immunohistochemistry of gastrointestinal neuroendocrine neoplasms (GI-NENs).

Methods: A comprehensive literature search regarding gastrointestinal neuroendocrine neoplasms and CXCR4 was conducted using PubMed,Web of Science, and the Cochrane Library, with a cut off date of June 30, 2024.Two researchers independently screened the literature according to inclusion and exclusion criteria and assessed study quality using the Newcastle-OttawaScale. Meta-analysis was performed using Stata version 17.0. The pooled positive rate was employed to evaluate the expression of CXCR4 in the immunohistochemistry of GI-NENs.

Results: A total of eight studies involving 501 patients were included in this research. The immunohistochemical analysis revealed positive CXCR4 expression in 174 patients. The meta-analysis calculated and summarized the combined positive rate (R: 0.41; 95% CI = 0.21-0.60, p = 0.00), indicating that the differences were statistically significant.

Conclusion: CXCR4 is highly expressed in the immunohistochemistry of GI-NENs, which may provide some evidence for the therapeutic application of CXCR4 antagonists in treating neuroendocrine neoplasms.

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CXCR4在胃肠道神经内分泌肿瘤免疫组织化学中的表达：一项meta分析。

目的：C-X-C趋化因子受体4型（CXCR4）与多种恶性肿瘤的发生发展有显著相关性。本荟萃分析旨在探讨CXCR4在胃肠道神经内分泌肿瘤（GI-NENs）免疫组织化学中的表达。方法：通过PubMed、Web of Science和Cochrane Library对胃肠道神经内分泌肿瘤和CXCR4进行全面的文献检索，截止日期为2024年6月30日。两名研究人员根据纳入和排除标准独立筛选文献，并使用纽卡斯尔-渥太华量表评估研究质量。meta分析采用Stata 17.0版本。采用合并阳性率评价CXCR4在GI-NENs免疫组化中的表达。结果：本研究共纳入8项研究，涉及501例患者。免疫组化分析显示174例患者中CXCR4表达阳性。meta分析计算并总结了合并阳性率(R: 0.41；95% CI = 0.21-0.60, p = 0.00)，差异有统计学意义。结论：CXCR4在GI-NENs免疫组化中高表达，可能为CXCR4拮抗剂在神经内分泌肿瘤治疗中的应用提供依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of immunoassay & immunochemistry 医学-免疫学

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal of Immunoassay & Immunochemistry is an international forum for rapid dissemination of research results and methodologies dealing with all aspects of immunoassay and immunochemistry, as well as selected aspects of immunology. They include receptor assay, enzyme-linked immunosorbent assay (ELISA) in all of its embodiments, ligand-based assays, biological markers of ligand-receptor interaction, in vivo and in vitro diagnostic reagents and techniques, diagnosis of AIDS, point-of-care testing, clinical immunology, antibody isolation and purification, and others.