Developing an anticoagulant microfibrous vascular graft with enhanced kink resistance and self-sealing capabilities

IF 6 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS Materials Science & Engineering C-Materials for Biological Applications Pub Date : 2025-08-01 Epub Date: 2025-03-24 DOI:10.1016/j.bioadv.2025.214290

Qing He , Chubo Huang , Yaming Lu , Yuan Zhao , Meiyi Xing , Xiangwen Wang , Binbin Sun , Yiqian Zhu

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Abstract

For clinical treatment of end-stage renal disease (ESRD) patients, the development of vascular grafts possessing both puncture resistance and anticoagulant properties remains crucial for arteriovenous fistula establishment. In this study, small-diameter vascular conduits were engineered through electrospinning of polyurethane (PU) microfibers, incorporating polyethylene coil reinforcement within the graft wall architecture to confer kink resistance. The microporous structure of the grafts demonstrated effective self-sealing capabilities following needle perforation. Additionally, heparin immobilization was implemented on the luminal surface to optimize thromboresistance. Large animal implantation studies revealed that the PU vascular grafts exhibited immediate puncture feasibility, superior puncture durability, and maintained excellent hemodynamic patency in vivo, demonstrating significant translational potential for clinical hemodialysis applications.

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开发抗凝微纤维血管移植物，增强抗扭结和自密封能力

对于终末期肾病（ESRD）患者的临床治疗，血管移植物的发展既具有抗穿刺性又具有抗凝血性，对于建立动静脉瘘至关重要。在这项研究中，通过静电纺丝聚氨酯（PU）微纤维设计了小直径的血管导管，在接枝壁结构中加入聚乙烯线圈增强，以赋予扭结阻力。移植物的微孔结构在针穿孔后表现出有效的自密封能力。此外，在管腔表面实施肝素固定化以优化血栓抵抗。大型动物植入研究表明，PU血管移植物具有立即穿刺的可行性，优越的穿刺耐久性，并在体内保持良好的血流动力学通畅，在临床血液透析应用中具有重要的转化潜力。

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来源期刊

Materials Science & Engineering C-Materials for Biological Applications 工程技术-材料科学：生物材料

CiteScore

17.80

自引率

0.00%

发文量

501

审稿时长

27 days

期刊介绍： Biomaterials Advances, previously known as Materials Science and Engineering: C-Materials for Biological Applications (P-ISSN: 0928-4931, E-ISSN: 1873-0191). Includes topics at the interface of the biomedical sciences and materials engineering. These topics include: • Bioinspired and biomimetic materials for medical applications • Materials of biological origin for medical applications • Materials for "active" medical applications • Self-assembling and self-healing materials for medical applications • "Smart" (i.e., stimulus-response) materials for medical applications • Ceramic, metallic, polymeric, and composite materials for medical applications • Materials for in vivo sensing • Materials for in vivo imaging • Materials for delivery of pharmacologic agents and vaccines • Novel approaches for characterizing and modeling materials for medical applications Manuscripts on biological topics without a materials science component, or manuscripts on materials science without biological applications, will not be considered for publication in Materials Science and Engineering C. New submissions are first assessed for language, scope and originality (plagiarism check) and can be desk rejected before review if they need English language improvements, are out of scope or present excessive duplication with published sources. Biomaterials Advances sits within Elsevier''s biomaterials science portfolio alongside Biomaterials, Materials Today Bio and Biomaterials and Biosystems. As part of the broader Materials Today family, Biomaterials Advances offers authors rigorous peer review, rapid decisions, and high visibility. We look forward to receiving your submissions!