Isotretinoin use in rhinoplasty patients

IF 1.8 4区医学 Q2 OTORHINOLARYNGOLOGY Brazilian Journal of Otorhinolaryngology Pub Date : 2025-07-01 Epub Date: 2025-03-26 DOI:10.1016/j.bjorl.2025.101592

Jholbert Cardoso Santana, Hugo Valter Ramos Lisboa, Leandro Azevedo de Camargo, Ricardo Araújo Meira Almeida, Lourival Mendes Bueno

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Abstract

Objective

Presenting evidence available on perioperative isotretinoin application in, and benefits for, thick-skinned patients subjected to rhinoplasty.

Methods

Analysis was applied to articles available in the following databases: Cochrane, PubMed, ScienceDirect and Scielo. The analyzed corpus comprised studies published from 2004 to 2023 focused on investigating thick-skinned patients subjected to rhinoplasty and treated with isotretinoin. Inappropriate and unrelated methodologies were excluded from the analysis.

Results

Initially, 1,214 articles were collected, but this number dropped to 617 after duplicates’ removal. Twenty (20) articles remained in the corpus after inclusion criteria application, but 10 of them were excluded from the analysis based on exclusion criteria. Finally, 10 articles were selected for review purposes: 1 experience report, 2 case studies, 3 narrative reviews and 4 clinical trials.

Conclusions

The current findings suggested aesthetic improvements in patients treated with isotretinoin, although its long-term benefits remain uncertain. Thus, further research on this topic should be conducted.

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异维甲酸在鼻整形患者中的应用

目的探讨异维甲酸在厚皮鼻整形患者围手术期的应用及疗效。方法采用Cochrane、PubMed、ScienceDirect和Scielo数据库中的文章进行分析。所分析的主体包括2004年至2023年发表的研究，重点是调查接受鼻整形术并接受异维甲酸治疗的厚皮患者。不适当和不相关的方法被排除在分析之外。结果最初收集了1214篇文章，但在删除重复后，这一数字下降到617篇。应用纳入标准后，语料库中仍有20篇文章，但其中10篇根据排除标准被排除在分析之外。最终，我们选择了10篇文章进行综述：1篇经验报告，2篇案例研究，3篇叙述性综述，4篇临床试验。结论：目前的研究结果表明，异维a酸治疗可以改善患者的审美，尽管其长期效益仍不确定。因此，需要对这一课题进行进一步的研究。

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来源期刊

Brazilian Journal of Otorhinolaryngology OTORHINOLARYNGOLOGY-

CiteScore

3.00

自引率

0.00%

发文量

205

审稿时长

4-8 weeks

期刊介绍： Brazilian Journal of Otorhinolaryngology publishes original contributions in otolaryngology and the associated areas (cranio-maxillo-facial surgery and phoniatrics). The aim of this journal is the national and international divulgation of the scientific production interesting to the otolaryngology, as well as the discussion, in editorials, of subjects of scientific, academic and professional relevance. The Brazilian Journal of Otorhinolaryngology is born from the Revista Brasileira de Otorrinolaringologia, of which it is the English version, created and indexed by MEDLINE in 2005. It is the official scientific publication of the Brazilian Association of Otolaryngology and Cervicofacial Surgery. Its abbreviated title is Braz J Otorhinolaryngol., which should be used in bibliographies, footnotes and bibliographical references and strips.