HF-rTMS of the left DLPFC relieve headaches and enhance frontal-temporal connectivity in migraine

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY Clinical Neurophysiology Pub Date : 2025-05-01 Epub Date: 2025-03-22 DOI:10.1016/j.clinph.2025.03.019

Penghui Song , Siran Li , Yuxuan Shao , Shuxiang Zhu , Yuping Wang , Peng Xu , Hua Lin

{"title":"HF-rTMS of the left DLPFC relieve headaches and enhance frontal-temporal connectivity in migraine","authors":"Penghui Song , Siran Li , Yuxuan Shao , Shuxiang Zhu , Yuping Wang , Peng Xu , Hua Lin","doi":"10.1016/j.clinph.2025.03.019","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>Migraine is a neurological disorder linked to altered cortical excitability. High-frequency repetitive transcranial magnetic stimulation (HF-rTMS) is a promising non-invasive method for modulating nociceptive circuits, yet its precise mechanisms remain unclear. This study applied HF-rTMS to the left dorsolateral prefrontal cortex (DLPFC) and assessed brain network changes using transcranial magnetic stimulation combined with electroencephalography (TMS-EEG).</div></div><div><h3>Methods</h3><div>We analyzed dynamic brain connectivity in 15 migraine patients versus 15 healthy controls. A randomized, double-blind, sham-controlled trial evaluated a 14-day HF-rTMS (20 Hz) protocol in 28 migraine patients. Brain network reorganization and migraine severity, measured by the Visual Analog Scale (VAS) and monthly migraine days (MMD), were assessed both immediately after treatment and at a one-month follow-up.</div></div><div><h3>Results</h3><div>Migraine patients exhibited reduced left DLPFC connectivity compared to healthy controls. HF-rTMS significantly increased frontal-temporal network connectivity, correlating with a marked reduction in VAS and MMD scores (p < 0.001).</div></div><div><h3>Conclusion</h3><div>These findings provide novel evidence that HF-rTMS targeting the left DLPFC effectively alleviates migraine symptoms by enhancing frontal-temporal cortical plasticity.</div></div><div><h3>Significance</h3><div>This study highlights the potential of neuromodulation techniques in the treatment of migraine.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"173 ","pages":"Pages 166-172"},"PeriodicalIF":3.6000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Neurophysiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1388245725004353","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/22 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

Migraine is a neurological disorder linked to altered cortical excitability. High-frequency repetitive transcranial magnetic stimulation (HF-rTMS) is a promising non-invasive method for modulating nociceptive circuits, yet its precise mechanisms remain unclear. This study applied HF-rTMS to the left dorsolateral prefrontal cortex (DLPFC) and assessed brain network changes using transcranial magnetic stimulation combined with electroencephalography (TMS-EEG).

Methods

We analyzed dynamic brain connectivity in 15 migraine patients versus 15 healthy controls. A randomized, double-blind, sham-controlled trial evaluated a 14-day HF-rTMS (20 Hz) protocol in 28 migraine patients. Brain network reorganization and migraine severity, measured by the Visual Analog Scale (VAS) and monthly migraine days (MMD), were assessed both immediately after treatment and at a one-month follow-up.

Results

Migraine patients exhibited reduced left DLPFC connectivity compared to healthy controls. HF-rTMS significantly increased frontal-temporal network connectivity, correlating with a marked reduction in VAS and MMD scores (p < 0.001).

Conclusion

These findings provide novel evidence that HF-rTMS targeting the left DLPFC effectively alleviates migraine symptoms by enhancing frontal-temporal cortical plasticity.

Significance

This study highlights the potential of neuromodulation techniques in the treatment of migraine.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

左侧DLPFC的HF-rTMS缓解头痛并增强偏头痛的额颞叶连通性

目的：偏头痛是一种与皮层兴奋性改变有关的神经系统疾病。高频重复经颅磁刺激（HF-rTMS）是一种很有前途的非侵入性调节伤害性回路的方法，但其确切机制尚不清楚。本研究将高频- rtms应用于左背外侧前额叶皮层（DLPFC），并利用经颅磁刺激联合脑电图（TMS-EEG）评估脑网络的变化。方法我们分析了15例偏头痛患者和15例健康对照者的动态脑连通性。一项随机、双盲、假对照试验对28例偏头痛患者进行了为期14天的HF-rTMS （20 Hz）治疗方案评估。脑网络重组和偏头痛严重程度，通过视觉模拟量表（VAS）和每月偏头痛天数（MMD）来测量，在治疗后立即和一个月的随访中进行评估。结果与健康对照相比，偏头痛患者表现出左侧DLPFC连通性降低。HF-rTMS显著增加额颞叶网络连通性，与VAS和MMD评分显著降低相关(p <；0.001)。结论针对左侧DLPFC的HF-rTMS可通过增强额颞叶皮质可塑性有效缓解偏头痛症状。本研究强调了神经调节技术在偏头痛治疗中的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.