Prefrontal transcranial magnetic stimulation changes cortical excitability across local and distributed brain regions

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY Clinical Neurophysiology Pub Date : 2025-03-22 DOI:10.1016/j.clinph.2025.03.020

Zhen Zhen , Rui Guo , Bolin Tan , Ying Wang , Shuyan Shi , Yang Ye , Xianwei Che

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Abstract

Objective

This study sort to identify the continuous effects of repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (DLPFC-rTMS) on local and distributed brain activities.

Methods

In a double-blinded and sham-controlled design, 24 participants received either a real or sham DLPFC-rTMS session, with concurrent TMS-EEG being recorded at baseline, 5 and 60 min after stimulation.

Results

DLPFC stimulation induced immediate cortical excitability in the frontal regions, while a continuous effect was identified in the parietal cortex for up to 60 min. Moreover, this pattern of cortical excitability effects was reliably identified across TMS-induced field potentials and oscillations.

Conclusions

Single-session DLPFC stimulation induced both immediate and continuous cortical excitability effects for at least 60 min. The continuous cortical excitability change.

was most prominent over the parietal cortices.

Significance

These novel findings may inform the design of TMS treatment paradigms to optimise cortical excitability and potentially clinical efficacy.

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前额叶经颅磁刺激改变局部和分布脑区的皮质兴奋性

目的探讨经颅重复磁刺激（rTMS）对背外侧前额叶皮层（DLPFC-rTMS）局部和分布脑活动的连续性影响。方法采用双盲和假对照设计，24名受试者分别接受真实或虚假DLPFC-rTMS治疗，并在刺激后基线、5和60 min同时记录TMS-EEG。结果dlpfc刺激在额叶区立即引起皮层兴奋性，而在顶叶皮层持续作用长达60分钟。此外，这种皮层兴奋性效应的模式在tms诱导的场电位和振荡中得到了可靠的证实。结论单次DLPFC刺激可诱导立即性和连续性皮层兴奋性效应，持续时间至少为60 min。在顶叶皮层上最为明显。这些新发现可能为TMS治疗模式的设计提供信息，以优化皮质兴奋性和潜在的临床疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.