A. S. Zolotova, M. A. Orlova, V. V. Spiridonov, T. P. Trofimova, A. Yu. Lupatov, A. A. Yaroslavov, S. N. Kalmykov
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引用次数: 0
Abstract
Three-component (ternary) microgels based on carboxymethylcellulose and copper(ii) ions with the immobilized inhibitor of inducible NO synthase (N-(5,6-dihydro-4H-1,3-thiazin-2-yl)benzamide), as well as the activator of this enzyme (N-(4-isopropylphenyl)-N-(1-iminoethyl)piperidine-1-carbothioamide hydrobromide) were prepared. The hydrodynamic and electrokinetic characteristics of the microgels were studied and demonstrate an optimal size and high colloidal stability in both aqueous and physiological environments. The synthesized ternary microgels are characterized by high cytotoxicity causing apoptosis of leukemic Jurkat cells.
期刊介绍：
Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections:
General and Inorganic Chemistry;
Physical Chemistry;
Organic Chemistry;
Organometallic Chemistry;
Chemistry of Natural Compounds and Bioorganic Chemistry.
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