Biobased Physicochemical Reversible Dual-Cross-Linked Hydrogel: Self-Healing, Antibacterial, Antioxidant, and Hemostatic Properties for Diabetic Wound Healing

IF 5.4 2区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Biomacromolecules Pub Date : 2025-04-14 Epub Date: 2025-03-24 DOI:10.1021/acs.biomac.5c00087

Hanzhang Wang, Bin Lu, Junyi Zhou, Jieying Lai, Xue Zheng, Shuang-Zhuang Guo, Li-Ming Zhang

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Abstract

Skin wound healing remains challenging due to a lack of ideal wound dressings suitable for acute and chronic wounds. This study introduced a biocompatible hydrogel wound dressing, synthesized through a green chemistry approach, specifically designed to meet the dual needs of acute and chronic wound care. The innovative strategy utilized sustainable biomaterials, soy protein, and vanillin, to construct a physical–reversible chemical dual-cross-linked hydrogel exhibiting high mechanical strength, excellent adhesion, and toughness. Schiff base reversible covalent bonds enabled rapid self-healing within 10 s, significantly improving durability. In a rat liver hemorrhage model, the hydrogel rapidly sealed wounds, achieving effective hemostasis, indicating great potential for acute wound care. Furthermore, vanillin imparted the hydrogel with antimicrobial and antioxidant properties, effectively accelerating diabetic chronic wound healing. This safe and efficient advanced biobased hydrogel offers a novel perspective for wound treatment and holds significant promise for clinical applications.

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生物基物理化学可逆双交联水凝胶：糖尿病伤口愈合的自愈、抗菌、抗氧化和止血特性。

由于缺乏适合急性和慢性伤口的理想伤口敷料，皮肤伤口愈合仍然具有挑战性。本研究介绍了一种生物相容性水凝胶伤口敷料，通过绿色化学方法合成，专门设计用于满足急慢性伤口护理的双重需求。该创新策略利用可持续生物材料，大豆蛋白和香兰素，构建了物理可逆的化学双交联水凝胶，具有高机械强度，优异的附着力和韧性。希夫碱可逆共价键能在10秒内快速自愈，显著提高了耐久性。在大鼠肝出血模型中，水凝胶快速封闭伤口，实现有效止血，在急性伤口护理中具有很大的潜力。此外，香兰素赋予水凝胶抗菌和抗氧化性能，有效地加速糖尿病慢性伤口愈合。这种安全高效的先进生物基水凝胶为伤口治疗提供了新的视角，具有重要的临床应用前景。

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文献相关原料

公司名称

产品信息

麦克林

Soybean protein

阿拉丁

Sodium hydroxide

阿拉丁

Methanol

阿拉丁

Vanillin

来源期刊

Biomacromolecules 化学-高分子科学

CiteScore

10.60

自引率

4.80%

发文量

417

审稿时长

1.6 months

期刊介绍： Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine. Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.