Burkitt lymphoma in patients with chronic lymphocytic leukemia and other indolent B-cell lymphoid malignancies.

IF 2.2 4区医学 Q3 HEMATOLOGY Leukemia & Lymphoma Pub Date : 2025-08-01 Epub Date: 2025-03-25 DOI:10.1080/10428194.2025.2475337

Tadeusz Robak, Agnieszka Pluta, Pawel Robak, Agnieszka Janus, Ewa Wawrzyniak, Marcin Braun

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Abstract

The most common form of Richter transformation, observed in 90-95% of patients, is the transformation of chronic lymphocytic leukemia (CLL) into diffuse large B-cell lymphoma (DLBCL). CLL has also been found to transform into Hodgkin lymphoma, prolymphocytic leukemia, and, in extremely rare cases, into other hematological malignancies, including Burkitt lymphoma (BL). This manuscript discusses a case of CLL transforming into BL and reviews a rare collection of cases of Burkitt lymphoma or Burkitt-like lymphoma associated with CLL,B-cell prolymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, lymphoplasmacytic lymphoma and splenic marginal zone lymphoma. It covers the pathogenesis, prognosis, clinical characteristics, and treatment outcomes of Burkitt transformation in CLL and other indolent B-cell lymphoid malignancies patients. A comprehensive search was conducted using PubMed, Web of Science, and Google Scholar for articles published between January 1980 and December 2024 on chronic lymphocytic leukemia, Burkitt lymphoma, indolent lymphoma, mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma, 8q24/MYC rearrangement, Epstein-Barr virus-positive lymphoma, and translocation t(8;14)(q24;q32). Additional relevant publications were identified by reviewing the references cited in the selected articles.

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慢性淋巴细胞白血病和其他惰性b细胞恶性肿瘤患者的伯基特淋巴瘤。

在90-95%的患者中观察到的最常见的Richter转化形式是慢性淋巴细胞白血病（CLL）向弥漫性大b细胞淋巴瘤（DLBCL）的转化。CLL也可转化为霍奇金淋巴瘤、前淋巴细胞白血病，在极少数情况下，还可转化为其他血液系统恶性肿瘤，包括伯基特淋巴瘤（BL）。本文讨论了一例CLL转化为BL的病例，并回顾了罕见的与CLL相关的伯基特淋巴瘤或伯基特样淋巴瘤、b细胞前淋巴细胞白血病、套细胞淋巴瘤、滤泡性淋巴瘤、淋巴浆细胞淋巴瘤和脾边缘带淋巴瘤的病例。它涵盖了CLL和其他惰性b细胞恶性肿瘤患者Burkitt转化的发病机制、预后、临床特点和治疗结果。对1980年1月至2024年12月间发表的关于慢性淋巴细胞白血病、伯基特淋巴瘤、惰性淋巴瘤、套细胞淋巴瘤、滤泡性淋巴瘤、边缘带淋巴瘤、8q24/MYC重排、eb病毒阳性淋巴瘤和易位t(8;14)（q24;q32）的文章进行了全面检索。通过审查所选文章中引用的参考文献，确定了其他相关出版物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Leukemia & Lymphoma 医学-血液学

CiteScore

4.10

自引率

3.80%

发文量

384

审稿时长

1.8 months

期刊介绍： Leukemia & Lymphoma in its fourth decade continues to provide an international forum for publication of high quality clinical, translational, and basic science research, and original observations relating to all aspects of hematological malignancies. The scope ranges from clinical and clinico-pathological investigations to fundamental research in disease biology, mechanisms of action of novel agents, development of combination chemotherapy, pharmacology and pharmacogenomics as well as ethics and epidemiology. Submissions of unique clinical observations or confirmatory studies are considered and published as Letters to the Editor