Theranostic advances and the role of molecular imprinting in disease management

IF 4.1 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES iScience Pub Date : 2025-03-10 DOI:10.1016/j.isci.2025.112186

Eylul Gulsen Yilmaz , Beyza Nur Küçük , Yusuf Aslan , Özgecan Erdem , Yeşeren Saylan , Fatih Inci , Adil Denizli

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Abstract

Molecular imprinting has become an effective technology in the realm of diagnosing diseases, providing unparalleled specificity and sensitivity. This method is a promising trend in current medical research. This review examines the utilization of molecularly imprinted polymers (MIPs) in theranostic that integrates diagnostic functionalities for personalized medicine. The present work briefly discusses the fundamental concepts of molecular imprinting and how it has evolved into a versatile platform. Subsequently, the utilization of MIPs in the advancement of biosensors is focused, specifically emphasizing their contribution to the detection and diagnosis of diseases. The therapeutic potential of MIPs, focusing on targeted drug delivery and controlled release systems and the integration of MIPs into theranostic platforms is explored through case studies, showcasing the technology’s ability to simultaneously diagnose and treat diseases. Finally, we address the current challenges facing MIPs and discuss future perspectives, emphasizing the potential of this technology to revolutionize the next generation.

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治疗进展和分子印迹在疾病管理中的作用

分子印迹技术已成为疾病诊断领域的一项有效技术，具有无与伦比的特异性和敏感性。这种方法是当前医学研究的一个有前途的趋势。本文综述了分子印迹聚合物（MIPs）在治疗中的应用，整合了个性化医疗的诊断功能。目前的工作简要地讨论了分子印迹的基本概念，以及它是如何演变成一个通用的平台。随后，重点介绍了MIPs在生物传感器发展中的应用，特别强调了它们对疾病检测和诊断的贡献。通过案例研究探索了MIPs的治疗潜力，重点是靶向药物输送和控制释放系统，以及将MIPs整合到治疗平台中，展示了该技术同时诊断和治疗疾病的能力。最后，我们讨论了当前mip面临的挑战，并讨论了未来的前景，强调了该技术革新下一代的潜力。

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来源期刊

iScience Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

1.70%

发文量

1972

审稿时长

6 weeks

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