Malcolm Forbes M.B.B.S. , Tayler Watson M.B.B.S. , Duncan J. Topliss M.D. , Mojtaba Lotfaliany Ph.D. , Mohammadreza Mohebbi Ph.D. , Robyn L. Woods Ph.D. , John J. McNeil Ph.D. , Michael Berk MBB.Ch.
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引用次数: 0
Abstract
Objective
To investigate the association between thyroid-stimulating hormone (TSH) levels and depression in older adults.
Design
Prospective cohort study with an 11-year follow-up period.
Setting
Community-dwelling participants from the ASPirin in Reducing Events in the Elderly (ASPREE) randomized controlled trial and its follow-up observational study in Australia.
Participants
About 9,050 adults aged ≥70 years with baseline TSH measurements and depression assessments. Participants with thyroid cancer, baseline depression, or thyroid-altering medications were excluded.
Measurements
Depression was assessed annually using the Center for Epidemiological Studies Depression Scale (CES-D-10) using a cut score of 12, and hospital admission records. TSH was measured at baseline and year 3, categorized as low (<0.34 mU/L), normal (0.34–3.75 mU/L), or high (>3.75 mU/L).
Results
Cross-sectional analyses found no significant association between TSH levels and depression at baseline (p = 0.79) or year 3 (p = 0.054). Longitudinal analyses revealed no relationship between baseline or time-varying TSH levels and incident depression over the follow-up period (HR = 1.0, 95% CI: 0.96–1.05).
Conclusions
TSH levels are not associated with prevalent or incident depression in older community-dwelling adults. These findings should guide screening approaches for depression in older adults.
期刊介绍：
The American Journal of Geriatric Psychiatry is the leading source of information in the rapidly evolving field of geriatric psychiatry. This esteemed journal features peer-reviewed articles covering topics such as the diagnosis and classification of psychiatric disorders in older adults, epidemiological and biological correlates of mental health in the elderly, and psychopharmacology and other somatic treatments. Published twelve times a year, the journal serves as an authoritative resource for professionals in the field.
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