Mother-child exposure to polychlorinated biphenyls and organochlorine pesticides in the Northern Finland cohort (NUGEN)

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES Environmental toxicology and pharmacology Pub Date : 2025-04-01 Epub Date: 2025-03-23 DOI:10.1016/j.etap.2025.104679

Saranya Palaniswamy , Soha Salah , Petra Přibylová , Petr Kukučka , Liisa Laatio , Elina Sieppi , Maria Kummu , Arja Rautio , Päivi Myllynen , Khaled Abass

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Abstract

Limited knowledge exists on persistent organic pollutants (POPs), including polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs), in mother-child pairs from Northern Finland. This study examines plasma PCB and OCP concentrations and their determinants. Blood plasma concentrations of 13 PCBs and 6 OCPs were measured in mothers and in cord samples from the NUGEN birth cohort (N = 102, 2012–2014). Correlations between maternal and cord POPs were assessed using Spearman correlation, and linear regression identified factors influencing lipid-adjusted POPs. Maternal age and alcohol consumption during pregnancy were positively associated with PCBs and OCPs. Pre-pregnancy BMI and weight change during pregnancy were inversely associated with PCBs, but positively with p,p’-DDE in children. Increasing parity and smoking were associated with lower PCBs. Maternal fish consumption was associated with higher PCBs in children. Finnish pregnant women had lower PCBs and OCPs than other European populations. These findings inform exposure risk assessment and prevention strategies.

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芬兰北部队列（NUGEN）中母亲对多氯联苯和有机氯农药的暴露。

芬兰北部母婴对持久性有机污染物（POPs），包括多氯联苯（PCBs）和有机氯农药（ocp）的了解有限。本研究检查血浆多氯联苯和OCP浓度及其决定因素。在NUGEN出生队列（N = 102, 2012-2014）的母亲和脐带样本中测量了13种多氯联苯和6种ocp的血浆浓度。使用Spearman相关性评估母体和脐带持久性有机污染物之间的相关性，并用线性回归确定影响脂质调节持久性有机污染物的因素。孕妇年龄和孕期饮酒与多氯联苯和ocp呈正相关。孕前BMI和孕期体重变化与多氯联苯呈负相关，但与儿童p，p′-DDE呈正相关。增加平价和吸烟与低多氯联苯有关。母亲食用鱼类与儿童多氯联苯含量较高有关。芬兰孕妇的多氯联苯和ocp含量低于其他欧洲人群。这些发现为暴露风险评估和预防策略提供了信息。

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.