Prevalence, distribution and future projections of Parkinson disease in Brazil: insights from the ELSI-Brazil cohort study

IF 7 Q1 HEALTH CARE SCIENCES & SERVICES Lancet Regional Health-Americas Pub Date : 2025-04-01 Epub Date: 2025-03-28 DOI:10.1016/j.lana.2025.101046

Thomas Hugentobler Schlickmann , Marcelo Somma Tessari , Wyllians Vendramini Borelli , Gabriel Alves Marconi , Gabriela Magalhães Pereira , Eduardo Zimmer , Alastair Noyce , Ignacio Fernandez Mata , Carlos Roberto de Mello Rieder , Daniel Teixeira-dos-Santos , Artur Francisco Schumacher Schuh

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Abstract

Background

There is limited epidemiological data regarding Parkinson's disease (PD) prevalence in Brazil, which hinders adequate public health policies planning and patient care. This study aimed to investigate the distribution, prevalence, and clinical characteristics of PD among older adults in Brazil.

Methods

This cross-sectional study used data from the ELSI-Brazil cohort, a Brazilian nationally representative study of individuals aged 50 and older. Data were collected through door-to-door surveys with standardized questionnaires. PD diagnosis was based on self-reported data. We calculated PD prevalence in the general population and specific age groups, studied its association with clinical variables, and projected PD prevalence in Brazil from 2024 to 2060.

Findings

A total of 9881 respondents were included in this study, and 93 reported a medical diagnosis of PD. The crude prevalence of PD among Brazilians aged 50 or more was 0.84% (95% CI: 0.64%–1.09%), with an age- and sex-standardized prevalence of 0.86% (95% CI: 0.62%–1.10%). Men were more affected than women (OR: 2.35, 95% CI: 1.35–4.08; p < 0.01), and the prevalence was higher in older age groups, from 0.39% in those aged 50–59 years to 2.75% in those 80 years and older. PD individuals had higher rates of stroke, depression, functional dependency, and were more likely to need walking support or be bedridden. Projections indicated that PD cases in Brazil will rise from 535,999 (95% CI: 309,963–922,948) in 2024 to 1,250,638 (95% CI: 734,660–2,117,585) by 2060.

Interpretation

This study reveals the prevalence and distribution of PD in Brazil, showing many patients with advanced disease and suggesting underdiagnosis in early stages. There is a need for better diagnostic accuracy, improved access to neurologists, and comprehensive public health strategies to manage the rising prevalence and healthcare demands of PD in Brazil.

Funding

This study did not receive any funding. The ELSI-Brazil cohort was funded by the Ministry of Health of Brazil.

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巴西帕金森病的患病率、分布和未来预测：来自elsi -巴西队列研究的见解

关于巴西帕金森病（PD）患病率的流行病学数据有限，这阻碍了充分的公共卫生政策规划和患者护理。本研究旨在调查巴西老年人帕金森病的分布、患病率和临床特征。方法：本横断面研究使用的数据来自elsi -巴西队列，这是一项针对50岁及以上人群的巴西全国代表性研究。数据是通过标准化问卷的上门调查收集的。PD诊断基于自我报告的数据。我们计算了一般人群和特定年龄组的PD患病率，研究了其与临床变量的关系，并预测了2024年至2060年巴西的PD患病率。研究结果共纳入9881名调查对象，其中93人报告了PD的医学诊断。50岁及以上的巴西人PD粗患病率为0.84% (95% CI: 0.64%-1.09%)，年龄和性别标准化患病率为0.86% （95% CI: 0.62%-1.10%）。男性比女性受影响更大(OR: 2.35, 95% CI: 1.35-4.08；p & lt;年龄越大患病率越高，50 ~ 59岁患病率为0.39%，80岁及以上患病率为2.75%。PD患者中风、抑郁、功能依赖的发生率更高，更有可能需要行走支持或卧床不起。预测显示，巴西PD病例将从2024年的535,999例（95% CI: 309,963-922,948）上升到2060年的1,250,638例（95% CI: 734,660-2,117,585）。本研究揭示了PD在巴西的患病率和分布，显示许多患者疾病晚期，提示早期诊断不足。有必要提高诊断的准确性，改善与神经科医生的接触，并制定全面的公共卫生战略，以管理巴西PD患病率的上升和医疗保健需求。本研究未获得任何资助。elsi -巴西队列由巴西卫生部资助。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lancet Regional Health-Americas Multiple-

CiteScore

8.00

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0.00%

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期刊介绍： The Lancet Regional Health – Americas, an open-access journal, contributes to The Lancet's global initiative by focusing on health-care quality and access in the Americas. It aims to advance clinical practice and health policy in the region, promoting better health outcomes. The journal publishes high-quality original research advocating change or shedding light on clinical practice and health policy. It welcomes submissions on various regional health topics, including infectious diseases, non-communicable diseases, child and adolescent health, maternal and reproductive health, emergency care, health policy, and health equity.