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Reassessing Spinola et al.: data, sources, and the case for Brazil's e-cigarette ban 重新评估Spinola等人:巴西电子烟禁令的数据、来源和案例
IF 7 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2026-02-07 DOI: 10.1016/j.lana.2026.101387
Andre Luiz Oliveira da Silva , Stanton A. Glantz
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引用次数: 0
The Latin American Diabetes Association 2025 congress 拉丁美洲糖尿病协会2025年大会
IF 7 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2026-02-01 DOI: 10.1016/j.lana.2026.101378
Orison O. Woolcott
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引用次数: 0
From detecting abnormalities to diagnosing cancer: how can lay anal examinations be refined? 从发现异常到诊断癌症:如何改进肛门检查?
IF 7 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2026-02-01 DOI: 10.1016/j.lana.2026.101380
Ming Wang, Yanru Cao, Qing Zhu
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引用次数: 0
Corrigendum to “Impact of strategic public health interventions to reduce tuberculosis incidence in Brazil: a Bayesian structural time-series scenario analysis” - The Lancet Regional Health – Americas 2025; Volume 41: 100963; DOI: 10.1016/j.lana.2024.100963 《战略公共卫生干预措施对减少巴西结核病发病率的影响:贝叶斯结构时序情景分析》的更正——《柳叶刀》区域卫生——2025年美洲版;卷41:100963;DOI: 10.1016 / j.lana.2024.100963
IF 7 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2026-02-01 DOI: 10.1016/j.lana.2026.101381
Klauss Villalva-Serra , Beatriz Barreto-Duarte , Moreno M. Rodrigues , Artur T.L. Queiroz , Leonardo Martinez , Julio Croda , Valeria C. Rolla , Afrânio L. Kritski , Marcelo Cordeiro-Santos , Timothy R. Sterling , Mariana Araújo-Pereir , Bruno B. Andrade
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引用次数: 0
Reassessing combined exercise–tDCS strategies in chronic pain 重新评估慢性疼痛的运动- tdcs联合策略
IF 7 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2026-01-29 DOI: 10.1016/j.lana.2026.101379
Stéphane Perrey
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引用次数: 0
‘Strategic approaches to reducing the substance use-related burden of disease in Canada’ — authors' reply “减少加拿大药物使用相关疾病负担的战略方法”——作者回复
IF 7 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2026-01-29 DOI: 10.1016/j.lana.2026.101376
Benedikt Fischer , Wayne Hall , Bernard Le Foll , Patricia Conrod
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引用次数: 0
Long-term effects of cooking with liquefied petroleum gas or biomass on linear growth trajectories from birth to the pre-school years in Puno, Peru: a prospective cohort study 在秘鲁普诺,用液化石油气或生物质烹饪对从出生到学龄前的线性生长轨迹的长期影响:一项前瞻性队列研究
IF 7 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2026-01-28 DOI: 10.1016/j.lana.2026.101382
Laura Nicolaou , Carolyn J. Reuland , Mingling Yang , Kendra N. Williams , Stella M. Hartinger , Marilú Chiang , William Checkley

Background

Household air pollution (HAP) is a major global health risk. Observational studies link HAP exposure to impaired child growth, but randomized controlled trial (RCT) evidence is inconsistent.

Methods

We followed children born during an RCT of an 18-month liquefied petroleum gas (LPG) intervention among 800 pregnant women in Puno, Peru. We measured personal exposures to fine particulate matter (PM2.5) and carbon monoxide (CO) three times during pregnancy and three times during infancy. We measured length quarterly between birth and 12 months and height once between age 2–4 years. We assessed the effect of the LPG intervention on growth trajectories and evaluated exposure-response associations between height-for-age z-score (HAZ) and PM2.5 or CO exposures.

Findings

We revisited 683 children (mean age 34.0 ± 6.6 months, 49.3% male, 52.3% intervention). Mean HAZ at age 2–4 years was −0.92 ± 0.83 SDs in intervention children and −1.00 ± 0.80 SDs in controls (p = 0.33). In intention-to-treat analysis, the HAZ difference between groups was 0.08 SDs (95% CI −0.04 to 0.21) favoring the intervention. Neither prenatal nor postnatal PM2.5 or CO exposures were associated with HAZ. A 10 μg/m3 difference in prenatal and postnatal PM2.5 corresponded to a HAZ difference of −0.003 SDs (−0.011 to 0.005) and −0.001 SDs (−0.005 to 0.007), respectively. A 1 ppm difference in prenatal or postnatal CO corresponded to −0.009 SDs (−0.025 to 0.008) and 0.000 (−0.011 to 0.012), respectively.

Interpretation

Children of mothers randomized to LPG were not taller than controls. Personal PM2.5 or CO exposures did not influence child growth.

Funding

US National Institutes of Health; Bill & Melinda Gates Foundation.
家庭空气污染(HAP)是一个主要的全球健康风险。观察性研究将HAP暴露与儿童生长受损联系起来,但随机对照试验(RCT)证据不一致。方法:我们对秘鲁普诺市800名孕妇进行了为期18个月的液化石油气(LPG)干预的随机对照试验。我们在怀孕期间和婴儿期分别测量了三次个人接触细颗粒物(PM2.5)和一氧化碳(CO)的情况。我们在出生到12个月之间每季度测量一次身高,在2-4岁之间测量一次身高。我们评估了LPG干预对生长轨迹的影响,并评估了身高年龄z分数(HAZ)与PM2.5或CO暴露之间的暴露-反应关系。结果683例患儿复诊,平均年龄34.0±6.6个月,男性49.3%,干预52.3%。干预儿童2 ~ 4岁的平均HAZ为- 0.92±0.83 SDs,对照组为- 1.00±0.80 SDs (p = 0.33)。在意向治疗分析中,两组间的HAZ差异为0.08 SDs (95% CI - 0.04至0.21),有利于干预。产前和产后PM2.5或CO暴露均与HAZ无关。产前和产后PM2.5差异10 μg/m3对应的HAZ差异分别为- 0.003 SDs(- 0.011 ~ 0.005)和- 0.001 SDs(- 0.005 ~ 0.007)。产前或产后1 ppm的CO差异分别对应- 0.009 SDs(- 0.025至0.008)和0.000 SDs(- 0.011至0.012)。解释:随机接受液化石油气治疗的母亲的孩子身高不高于对照组。个人PM2.5或CO暴露对儿童生长没有影响。资助美国国立卫生研究院;比尔及梅琳达·盖茨基金会。
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引用次数: 0
Alcohol- and drug-related mortality in Brazil: an ecological and population-based study on changes observed during the COVID-19 pandemic 巴西与酒精和药物相关的死亡率:一项基于生态和人口的研究,研究了COVID-19大流行期间观察到的变化
IF 7 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2026-01-28 DOI: 10.1016/j.lana.2025.101371
Lucas Almeida Andrade , Maria Amélia dos Santos Lemos Gurgel , Wandklebson Silva da Paz , Glauber Rocha Monteiro , Karina Conceição Gomes de Araújo , Allan Dantas dos Santos , Carlos Dornels Freire de Souza , Álvaro Francisco Lopes de Sousa , Lariane Angel Cepas , Ana Paula Morais Fernandes , Débora dos Santos Tavares , Tatiana Rodrigues de Moura , Márcio Bezerra-Santos

Background

The COVID-19 pandemic has disrupted healthcare services and intensified socio-economic vulnerabilities, potentially escalating harmful substance use. In Brazil, pre-pandemic mortality from alcohol and drug use was stable. However, the pandemic introduced new risks that may have triggered a significant increase in related deaths. This study, therefore, aims to assess the impact of the COVID-19 pandemic on alcohol- and drug-related deaths in Brazil from 2020 to 2022.

Methods

This population-based ecological study analyzed alcohol- and drug-related mortality across Brazil from 2015 to 2022 using data from the Brazilian Mortality Information System (SIM). Temporal trends were examined using Joinpoint regression, while interrupted time-series analyses assessed deviations post-pandemic onset. Spatial variations were visualized using choropleth maps.

Findings

Alcohol- and drug-related mortality increased by 18.3% in 2020, 22.4% in 2021, and 26.0% in 2022. The Northeast (2020 = 24.9%; 2021 = 24.0%; 2022 = 31.8%), Southeast (2020 = 18.2%; 2021 = 24.3%; 2022 = 21.0%), and South (2020 = 13.1%; 2021 = 23.6%; 2022 = 35.2%) regions recorded the highest increases, with most states showing significant growth in deaths. We also observed an increase in mortality associated with the use of Psychoactive substances (PAS) in both sexes (male: average annual percentage changes (AAPCs) = 3.6%; female: AAPC = 4.6%), individuals aged 20 to 39 (AAPC = 2.0%), and those aged 60 and above (AAPC = 1.8%). Interrupted time-series analyses confirmed a marked and statistically significant increase in mortality post-March 2020.

Interpretation

The findings suggest a collateral epidemic of substance-related deaths fueled by the COVID-19 pandemic's disruptions to harm reduction services, treatment access, and socio-economic stability. These results underscore the urgent need to enhance healthcare systems, reinforce harm reduction services, and develop intersectoral policies targeting social inequalities to mitigate future crises.

Funding

This research is part of the PEGA@ACAO study and was funded by the São Paulo Research Foundation (FAPESP, grant #2024/15320-5 and #2025/04763-6); the National Council for Scientific and Technological Development (CNPq, grant #405741/2024-3); and the Coordination for the Improvement of Higher Education Personnel (CAPES, finance code #001).
2019冠状病毒病大流行扰乱了卫生保健服务,加剧了社会经济脆弱性,可能加剧有害物质的使用。在巴西,大流行前酗酒和吸毒造成的死亡率是稳定的。然而,大流行带来了新的风险,可能导致相关死亡人数大幅增加。因此,本研究旨在评估2020年至2022年COVID-19大流行对巴西酒精和药物相关死亡的影响。方法:这项基于人群的生态研究使用巴西死亡率信息系统(SIM)的数据,分析了2015年至2022年巴西各地酒精和药物相关的死亡率。使用连接点回归检查了时间趋势,而中断时间序列分析评估了大流行开始后的偏差。空间变化使用地形图可视化。酒精和药物相关的死亡率在2020年增加了18.3%,2021年增加了22.4%,2022年增加了26.0%。东北部地区(2020年= 24.9%;2021年= 24.0%;2022年= 31.8%)、东南部地区(2020年= 18.2%;2021年= 24.3%;2022年= 21.0%)和南部地区(2020年= 13.1%;2021年= 23.6%;2022年= 35.2%)的增长幅度最大,大多数州的死亡人数都出现了显著增长。我们还观察到两性中与精神活性物质(PAS)使用相关的死亡率增加(男性:平均年百分比变化(AAPCs) = 3.6%;女性:AAPC = 4.6%), 20 ~ 39岁(AAPC = 2.0%), 60岁及以上(AAPC = 1.8%)。中断时间序列分析证实,2020年3月以后死亡率显著上升,在统计上具有显著意义。研究结果表明,由于COVID-19大流行对减少危害服务、获得治疗和社会经济稳定的破坏,导致了与药物相关的死亡的附带流行。这些结果强调迫切需要加强卫生保健系统,加强减少伤害服务,并制定针对社会不平等的部门间政策,以减轻未来的危机。本研究是PEGA@ACAO研究的一部分,由圣保罗研究基金会(FAPESP,拨款#2024/15320-5和#2025/04763-6)资助;国家科学技术发展委员会(CNPq,批准号405741/2024-3);以及高等教育人员发展协调(CAPES,财务代码#001)。
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引用次数: 0
The prevalence of cannabis use pre-versus post-cannabis legalization in Canada by mental health status: findings from national repeat cross-sectional surveys 按心理健康状况分列的加拿大大麻合法化前后大麻使用的流行程度:全国重复横断面调查的结果
IF 7 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2026-01-19 DOI: 10.1016/j.lana.2026.101373
Samantha Rundle , Maryam Iraniparast , David Hammond

Background

The bidirectional relationship between cannabis use and mental health is complex. With the liberalization of cannabis laws in many countries, it is increasingly important to understand the impacts of cannabis legalization on individuals with mental health conditions. This study aimed to examine changes in cannabis use by mental health status pre-versus 5-years post-legalization of recreational cannabis in Canada.

Methods

Data were from the International Cannabis Policy Study's national repeat cross-sectional surveys, conducted annually in Canada between 2018 and 2023, one year before and five years after the legalization of cannabis. The current analysis includes 92,843 Canadians aged 16–65 years. Adjusted logistic regression models examined changes in daily and past 12-month cannabis use pre-versus post-legalization among individuals experiencing each of the five mental health problems in the last year: anxiety, bipolar, depression, post-traumatic stress disorder (PTSD), and schizophrenia.

Findings

Past 12-month cannabis consumption increased from pre-legalization versus the year immediately following legalization (2019) among those with anxiety (adjusted odds ratio (AOR) = 1.33, 95% CI = 1.15, 1.53, p < 0.0001), depression (AOR = 1.47, 95% CI = 1.26, 1.73, p < 0.0001), and those reporting ‘no experience’ of a mental health problem in the past year (AOR = 1.52, 95% CI = 1.37, 1.68, p < 0.0001). Past 12-month cannabis use remained significantly higher in 2023 versus pre-legalization for anxiety and depression. Daily cannabis use increased from 2018 to 2019 only among those not reporting any experience of a mental health problem in the past year (AOR = 1.34, 95% CI = 1.10, 1.62, p < 0.0001). No other pre-post legalization differences were observed among individuals who experienced bipolar, PTSD, or schizophrenia.

Interpretation

Few changes in cannabis use were observed pre-versus post-cannabis legalization among Canadians who reported experiencing a mental health problem, whereas daily and past 12-month use increased among Canadians not reporting a mental health problem.

Funding

Funding for the ICPS study was provided by a Canadian Institutes of Health Research Project Grant and Project Bridge Grant (PJT-153342).
大麻使用与心理健康之间的双向关系是复杂的。随着许多国家大麻法律的放宽,了解大麻合法化对有精神健康问题的个人的影响变得越来越重要。本研究旨在研究加拿大娱乐性大麻合法化前与5年后大麻使用心理健康状况的变化。方法数据来自国际大麻政策研究的全国重复横断面调查,该调查于2018年至2023年在加拿大进行,分别是大麻合法化的前一年和后五年。目前的分析包括92,843名年龄在16-65岁之间的加拿大人。调整后的逻辑回归模型检查了去年经历五种精神健康问题(焦虑、双相情感障碍、抑郁、创伤后应激障碍和精神分裂症)的个体在大麻合法化前和合法化后每天和过去12个月大麻使用情况的变化。研究发现,与合法化后的一年(2019年)相比,过去12个月的大麻消费量在焦虑(调整优势比(AOR) = 1.33, 95% CI = 1.15, 1.53, p < 0.0001)、抑郁(AOR = 1.47, 95% CI = 1.26, 1.73, p < 0.0001)和报告在过去一年中“没有经历”精神健康问题的人(AOR = 1.52, 95% CI = 1.37, 1.68, p < 0.0001)中有所增加。与合法化前相比,2023年过去12个月的大麻使用量仍明显高于焦虑和抑郁。从2018年到2019年,只有在过去一年没有任何精神健康问题经历的人群中,每日大麻使用量有所增加(AOR = 1.34, 95% CI = 1.10, 1.62, p < 0.0001)。在经历过双相情感障碍、创伤后应激障碍或精神分裂症的个体中,没有观察到其他的合法化前后差异。解释在报告有精神健康问题的加拿大人中,大麻使用在大麻合法化之前和之后几乎没有变化,而在报告没有精神健康问题的加拿大人中,每天和过去12个月的大麻使用有所增加。ICPS研究的资金由加拿大卫生研究院项目资助和项目桥梁资助(PJT-153342)提供。
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引用次数: 0
Advancing maternal and child health and nutrition in Ecuador: a call for research 促进厄瓜多尔妇幼保健和营养:呼吁开展研究
IF 7 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2026-01-14 DOI: 10.1016/j.lana.2026.101377
Taissa Vila, Orison O. Woolcott
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引用次数: 0
期刊
Lancet Regional Health-Americas
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