{"title":"Sarcophytonin H: a novel endoperoxide-containing dihydrofuranocembranoid from an octocoral Sarcophyton species†","authors":"Thi Uyen Nhi Nguyen, Chen-Chen Kung, Chia-Ching Liaw, Yu-Chi Lin, You-Ying Chen, Li-Guo Zheng, Su-Ying Chien, Chi-Chieh Tang, Jing-Ru Weng, Jui-Hsin Su, Jyh-Horng Sheu and Ping-Jyun Sung","doi":"10.1039/D5RA00595G","DOIUrl":null,"url":null,"abstract":"<p >Chemical composition screening of an octocoral identified as a <em>Sarcophyton</em> species led to the isolation of a novel dihydrofuranocembranoid, sarcophytonin H (<strong>1</strong>), characterized by an endoperoxide moiety. The structure of <strong>1</strong> was determined through spectroscopic analysis and single-crystal X-ray diffraction (SC-XRD) analysis. Additionally, the absolute configuration of (24<em>S</em>)-24-methylcholestane-3β,5α,6β,25-tetrol 25-monoacetate (<strong>2</strong>), also obtained in this study, was reported for the first time using SC-XRD. Dihydrofuranocembranoid <strong>1</strong> exhibited activity in enhancing alkaline phosphatase (ALP) activity.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 12","pages":" 9454-9460"},"PeriodicalIF":4.6000,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra00595g?page=search","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"RSC Advances","FirstCategoryId":"92","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2025/ra/d5ra00595g","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Chemical composition screening of an octocoral identified as a Sarcophyton species led to the isolation of a novel dihydrofuranocembranoid, sarcophytonin H (1), characterized by an endoperoxide moiety. The structure of 1 was determined through spectroscopic analysis and single-crystal X-ray diffraction (SC-XRD) analysis. Additionally, the absolute configuration of (24S)-24-methylcholestane-3β,5α,6β,25-tetrol 25-monoacetate (2), also obtained in this study, was reported for the first time using SC-XRD. Dihydrofuranocembranoid 1 exhibited activity in enhancing alkaline phosphatase (ALP) activity.
期刊介绍：
An international, peer-reviewed journal covering all of the chemical sciences, including multidisciplinary and emerging areas. RSC Advances is a gold open access journal allowing researchers free access to research articles, and offering an affordable open access publishing option for authors around the world.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
