Synthesis of Novel Substituted 4-[1-(1-Phenyl-1H-[1,2,3]triazol-4-yl-methyl)-1H-benzimidazol-2-yl]piperidine-1-carboxylic Acids tert-Butyl Esters. Evaluation of Cytotoxic and Antimicrobial Activity

Abstract

A straightforward and effective method for the synthesis of new series of benzimidazole-triazole hybrids developed by adopting click Cu(I)-catalyzed 1,3-dipolar cycloaddition. Alkyne tethered benzimidazole carboxylates treated with various aromatic azides using sodium ascorbate and copper sulphate as catalytic medium. The resulting series of novel benzimidazole-linked 1,2,3-triazole analogues were characterized using NMR, IR, mass spectral data. All the compounds screened for cytotoxic and antimicrobial activity. Three compounds exhibited good cytotoxic as well as antimicrobial activity