Treatment of Port-Wine Birthmarks Using a Large-Spot, Variable Sequenced, Long-Pulsed KTP-Laser—A Retrospective Analysis

IF 2.5 4区医学 Q2 DERMATOLOGY Journal of Cosmetic Dermatology Pub Date : 2025-03-28 DOI:10.1111/jocd.70152

Lynhda Nguyen, Stefan W. Schneider, Katharina Herberger

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Abstract

Background

Pulsed-dye lasers (PDLs) are currently regarded as the gold standard for treating port-wine birthmarks (PWBs). Recently, the large-spot, variable-sequenced, long-pulsed potassium titanyl phosphate laser (KTP) has been introduced as a promising alternative for addressing dermatologic vascular lesions. Despite its growing use, data on the efficacy and safety of this technology in treating PWBs over an extended period remain limited.

Aims

To evaluate the efficacy and safety of a large-spot, variable-sequenced, long-pulsed KTP in the treatment of PWBs over 3 years.

Methods

A retrospective analysis was conducted on PWB patients treated with the KTP between October 2021 and October 2024. Treatment outcomes were assessed using colorimetric analysis based on the CIE L*a*b* color space system and by measuring the surface area of the lesions. All adverse events (AEs) were documented.

Results

A total of 69 patients were included, with a mean age of 36.5 ± 15.6 years. 59.4% were female. Colorimetric analysis revealed an average lightening of PWBs by 75.7% ± 36.1%. Additionally, the surface area of the lesions decreased by 25.3% ± 24.4%. No severe AEs, such as post-inflammatory hyperpigmentation or scarring, were observed.

Conclusion

This study highlights the potential of large-spot, variable-pulsed KTP as a safe and effective alternative for treating PWBs, demonstrating significant lesion lightening and surface area reduction. With no severe AEs observed, the findings suggest that this technology could complement or serve as an alternative to PDLs. Further prospective studies are warranted to optimize treatment protocols and evaluate long-term outcomes compared to PDL and other vascular treatment options.

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大斑点、可变序列、长脉冲ktp激光治疗葡萄酒胎记的回顾性分析

背景：脉冲染料激光（PDLs）目前被认为是治疗葡萄酒胎记（PWBs）的金标准。最近，大斑点、可变序列、长脉冲磷酸钛基钾激光（KTP）作为一种治疗皮肤血管病变的有希望的替代方法被引入。尽管使用越来越多，但关于该技术在长期治疗PWBs方面的有效性和安全性的数据仍然有限。目的评价大点、可变序列、长脉冲KTP治疗3年以上PWBs的疗效和安全性。方法回顾性分析2021年10月至2024年10月期间接受KTP治疗的PWB患者。采用基于CIE L*a*b*颜色空间系统的比色分析和测量病变表面积来评估治疗效果。记录了所有不良事件（ae）。结果共纳入69例患者，平均年龄36.5±15.6岁。59.4%为女性。比色分析显示，印制板的平均减亮率为75.7%±36.1%。病变面积减少25.3%±24.4%。未观察到严重的不良反应，如炎症后色素沉着或瘢痕形成。结论：本研究强调了大斑点、可变脉冲KTP作为治疗PWBs的一种安全有效的替代方法的潜力，显示出显著的病变减轻和表面积减少。由于没有观察到严重的不良反应，研究结果表明该技术可以补充或替代pdl。与PDL和其他血管治疗方案相比，需要进一步的前瞻性研究来优化治疗方案并评估长期结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cosmetic Dermatology DERMATOLOGY-

CiteScore

4.30

自引率

13.00%

发文量

818

审稿时长

>12 weeks

期刊介绍： The Journal of Cosmetic Dermatology publishes high quality, peer-reviewed articles on all aspects of cosmetic dermatology with the aim to foster the highest standards of patient care in cosmetic dermatology. Published quarterly, the Journal of Cosmetic Dermatology facilitates continuing professional development and provides a forum for the exchange of scientific research and innovative techniques. The scope of coverage includes, but will not be limited to: healthy skin; skin maintenance; ageing skin; photodamage and photoprotection; rejuvenation; biochemistry, endocrinology and neuroimmunology of healthy skin; imaging; skin measurement; quality of life; skin types; sensitive skin; rosacea and acne; sebum; sweat; fat; phlebology; hair conservation, restoration and removal; nails and nail surgery; pigment; psychological and medicolegal issues; retinoids; cosmetic chemistry; dermopharmacy; cosmeceuticals; toiletries; striae; cellulite; cosmetic dermatological surgery; blepharoplasty; liposuction; surgical complications; botulinum; fillers, peels and dermabrasion; local and tumescent anaesthesia; electrosurgery; lasers, including laser physics, laser research and safety, vascular lasers, pigment lasers, hair removal lasers, tattoo removal lasers, resurfacing lasers, dermal remodelling lasers and laser complications.