The role of chloride intracellular channel 4 in tumors.

IF 6 2区医学 Q1 ONCOLOGY Cancer Cell International Pub Date : 2025-03-26 DOI:10.1186/s12935-025-03737-7

Xin Li, Yongfeng Wang, Minmin Ren, Qian Liu, Jiajia Li, Li Zhang, Shun Yao, Lulu Tang, Guorong Wen, Jiaxing An, Hai Jin, Biguang Tuo

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Abstract

Tumors are among the most predominant health problems in the world, and the annual incidence of cancer is increasing globally; therefore, there is an urgent need to identify effective therapeutic targets. Chloride intracellular channel 4 (CLIC4) belongs to the family of chloride intracellular channels (CLICs), which are widely expressed in various tissues and organs, such as the brain, lung, pancreas, colorectum, and ovary, and play important roles in promoting apoptosis, promoting angiogenesis, maintaining normal proliferation of endothelial cells, and regulating the assembly and reconstruction of the cytoskeleton. The expression and function of CLIC4 in tumors varies. It has been reported that CLIC4 is low expressed in gastric cancer, skin cancer and prostate cancer, suggesting a tumor suppressor role. Interestingly, CLIC4 is overexpressed in pancreatic, ovarian and breast cancers, indicating a cancer-promoting role. CLIC4 expression is dysregulated in some solid tumors, which may be because CLIC4 is involved in the growth, migration or invasion of some cancer cells through various mechanisms. Regulation of CLIC4 expression may be a potential therapeutic strategy for some tumors. CLIC4 may be a promising therapeutic target and a biomarker for some cancers. In this study, we review the role of CLIC4 in several cancers and its value in the diagnosis and treatment of tumors.

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细胞内氯离子通道4在肿瘤中的作用。

肿瘤是世界上最主要的健康问题之一，全球癌症的年发病率正在增加；因此，迫切需要确定有效的治疗靶点。细胞内氯离子通道4 （CLIC4）属于细胞内氯离子通道（CLICs）家族，广泛表达于脑、肺、胰腺、结直肠、卵巢等多种组织器官中，在促进细胞凋亡、促进血管生成、维持内皮细胞正常增殖、调节细胞骨架组装重建等方面发挥重要作用。CLIC4在肿瘤中的表达和功能各不相同。有报道称，CLIC4在胃癌、皮肤癌和前列腺癌中低表达，提示其具有抑癌作用。有趣的是，CLIC4在胰腺癌、卵巢癌和乳腺癌中过表达，表明其具有促癌作用。在一些实体肿瘤中，CLIC4表达失调，这可能是因为CLIC4通过多种机制参与了一些癌细胞的生长、迁移或侵袭。调节CLIC4的表达可能是一些肿瘤的潜在治疗策略。CLIC4可能是一个有希望的治疗靶点和一些癌症的生物标志物。在本研究中，我们回顾了CLIC4在几种癌症中的作用及其在肿瘤诊断和治疗中的价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Cell International ONCOLOGY-

CiteScore

10.90

自引率

1.70%

发文量

360

审稿时长

1 months

期刊介绍： Cancer Cell International publishes articles on all aspects of cancer cell biology, originating largely from, but not limited to, work using cell culture techniques. The journal focuses on novel cancer studies reporting data from biological experiments performed on cells grown in vitro, in two- or three-dimensional systems, and/or in vivo (animal experiments). These types of experiments have provided crucial data in many fields, from cell proliferation and transformation, to epithelial-mesenchymal interaction, to apoptosis, and host immune response to tumors. Cancer Cell International also considers articles that focus on novel technologies or novel pathways in molecular analysis and on epidemiological studies that may affect patient care, as well as articles reporting translational cancer research studies where in vitro discoveries are bridged to the clinic. As such, the journal is interested in laboratory and animal studies reporting on novel biomarkers of tumor progression and response to therapy and on their applicability to human cancers.