Association of ethylene oxide exposure with serum neurofilament light chain levels among American adults.

IF 3.4 3区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Frontiers in Public Health Pub Date : 2025-03-12 eCollection Date: 2025-01-01 DOI:10.3389/fpubh.2025.1545164

Xiuwen Yang, Huaili Feng, Ting You, Zhaoyi Liu, Fanwei Sun, Chengzhi Chen, Jingfu Qiu

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Abstract

Objective: To explore the relationship between Ethylene oxide (EO) expousure and serum neurofilament light chain (NfL).

Method: A data of 559 adults from the 2013-2014 National Health and Nutrition Examination Survey (NHANES) was analyzed, and the relationship between log-transformed EO hemoglobin adducts (HbEO) and serum NfL levels was assessed using multiple linear regression models and restricted cubic spline functions. Stratified analysis was conducted to explore the correlations within different subgroups. Mediation analysis was employed to investigate potential mediating factors.

Results: The higher HbEO levels were consistently associated with elevated serum NfL concentrations among the study participants (β = 0.07, 95%CI: 0.00-0.14; p = 0.044), and serum NfL levels increased with rising HbEO levels (p for trend = 0.013). The restricted cubic spline results confirmed the linear relationship between serum NfL and HbEO. Subgroup analysis indicated a significant positive correlation, particularly among non-Hispanic white people, individuals aged 40-59, and heavy drinkers.

Conclusion: These findings highlighted the neurotoxic potential of EO and underscored the importance of monitoring EO exposure to mitigate its adverse health effects.

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环氧乙烷暴露与美国成人血清神经丝轻链水平的关系

目的：探讨环氧乙烷（EO）暴露与血清神经丝轻链（NfL）的关系。方法：分析2013-2014年全国健康与营养调查（NHANES）中559名成年人的数据，采用多元线性回归模型和限制三次样条函数评估对数变换EO血红蛋白加合物（HbEO）与血清NfL水平的关系。进行分层分析，探讨不同亚组间的相关性。采用中介分析探讨潜在的中介因素。结果：在研究参与者中，较高的HbEO水平与血清NfL浓度升高一致相关(β = 0.07,95%CI: 0.00-0.14；p = 0.044)，血清NfL水平随HbEO水平升高而升高（趋势p = 0.013）。限制三次样条结果证实血清NfL与HbEO呈线性关系。亚组分析显示出显著的正相关，特别是在非西班牙裔白人、40-59岁的个体和酗酒者中。结论：这些发现突出了环氧乙烷的神经毒性潜力，并强调了监测环氧乙烷暴露以减轻其不良健康影响的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Public Health Medicine-Public Health, Environmental and Occupational Health

CiteScore

4.80

自引率

7.70%

发文量

4469

审稿时长

14 weeks

期刊介绍： Frontiers in Public Health is a multidisciplinary open-access journal which publishes rigorously peer-reviewed research and is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians, policy makers and the public worldwide. The journal aims at overcoming current fragmentation in research and publication, promoting consistency in pursuing relevant scientific themes, and supporting finding dissemination and translation into practice. Frontiers in Public Health is organized into Specialty Sections that cover different areas of research in the field. Please refer to the author guidelines for details on article types and the submission process.