{"title":"The mechanics of protein sweet spots","authors":"Qian-Yuan Tang","doi":"10.1038/s41567-025-02826-8","DOIUrl":null,"url":null,"abstract":"Proteins rely on dynamic flexibility to function as life’s molecular machines. Now, artificial intelligence predictions and mechanics experiments reveal how mutations at specific protein sites modulate enzyme catalysis, advancing protein design.","PeriodicalId":19100,"journal":{"name":"Nature Physics","volume":"21 5","pages":"695-696"},"PeriodicalIF":18.4000,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Physics","FirstCategoryId":"101","ListUrlMain":"https://www.nature.com/articles/s41567-025-02826-8","RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHYSICS, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Proteins rely on dynamic flexibility to function as life’s molecular machines. Now, artificial intelligence predictions and mechanics experiments reveal how mutations at specific protein sites modulate enzyme catalysis, advancing protein design.
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Nature Physics is dedicated to publishing top-tier original research in physics with a fair and rigorous review process. It provides high visibility and access to a broad readership, maintaining high standards in copy editing and production, ensuring rapid publication, and maintaining independence from academic societies and other vested interests.
The journal presents two main research paper formats: Letters and Articles. Alongside primary research, Nature Physics serves as a central source for valuable information within the physics community through Review Articles, News & Views, Research Highlights covering crucial developments across the physics literature, Commentaries, Book Reviews, and Correspondence.
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