{"title":"Optical control of an excitable enzyme circuit for engineering dynamic cell shapes","authors":"","doi":"10.1038/s41567-025-02810-2","DOIUrl":null,"url":null,"abstract":"Light-switchable enzymes hold great promise for mediating molecular activations in living cells, yet their full potential in realizing versatile controls in nonlinear networks remains unexplored. Now, optical control is demonstrated over a key enzyme involved in animal cell division, and a diverse array of dynamic cell shapes is achieved by biochemically hacking an endogenous signalling circuit.","PeriodicalId":19100,"journal":{"name":"Nature Physics","volume":"21 5","pages":"706-707"},"PeriodicalIF":18.4000,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Physics","FirstCategoryId":"101","ListUrlMain":"https://www.nature.com/articles/s41567-025-02810-2","RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHYSICS, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Light-switchable enzymes hold great promise for mediating molecular activations in living cells, yet their full potential in realizing versatile controls in nonlinear networks remains unexplored. Now, optical control is demonstrated over a key enzyme involved in animal cell division, and a diverse array of dynamic cell shapes is achieved by biochemically hacking an endogenous signalling circuit.
期刊介绍：
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The journal presents two main research paper formats: Letters and Articles. Alongside primary research, Nature Physics serves as a central source for valuable information within the physics community through Review Articles, News & Views, Research Highlights covering crucial developments across the physics literature, Commentaries, Book Reviews, and Correspondence.
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