Plan complexity and dosiomics signatures for gamma passing rate classification in volumetric modulated arc therapy: External validation across different LINACs

Abstract

Purpose

This study aims to enhance gamma passing rate (GPR) classification by integrating plan complexity signature, dosiomics signature, and comprehensive plan parameters, and to validate this method using data from different linear accelerators (LINACs).

Methods

This study included 235 volumetric modulated arc therapy (VMAT) treatment plans delivered using the TrueBeam LINAC as the primary dataset, along with 47 plans from the VitalBeam LINAC for external validation. The primary dataset was split into training (N = 166) and test (N = 69) subsets. Extracted features included 47 plan complexity metrics, 851 dosiomics features, and 20 plan parameters. Plan complexity score (PCscore) and dosiomics score (Doscore) were derived using the least absolute shrinkage and selection operator (LASSO). Four classification models were developed by combining PCscore, Doscore, and plan parameters according to a gamma criterion of 2 %/2 mm (γ2%/2 mm). A nomogram was constructed to combine these signatures with plan parameters. Model performance was evaluated using receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis (DCA).

Results

The combined model incorporating PCscore, Doscore, and plan parameters exhibited high discriminative power, with areas under the curve (AUC) of 0.894, 0.899, and 0.904 for the training, test, and external datasets, respectively. At γ3%/2 mm, the model maintained robust performance with AUCs of 0.842 and 0.833 in the test and external datasets. Calibration curves and DCA validated the model’s effectiveness.

Conclusions

Integrating plan complexity and dosiomics signatures with key plan parameters significantly improves GPR classification for VMAT treatment plans, offering a robust approach for patient-specific quality assurance (PSQA).