Fei Song , Jie Li , Bin-Bin Song , Zheng-Yi Shi , Zhang-Rong Hou , Ye-Ting Zhang , Yu-Lin Duan , Jian-Ping Wang , Chang-Xing Qi , Yong-Hui Zhang
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引用次数: 0
Abstract
The chemical study of Hypericum patulum provided a new degraded lupane-type triterpenoid, patutriter A (1), and seven known compounds (2–8). Their structures were identified by spectroscopic techniques and single crystal diffraction experiment. Structurally, patutriter A (1) was a new lupane with a 28-nor-skeleton. More importantly, compounds 3–5 exhibited moderate immunosuppressive effects that inhibit the anti-CD3/anti-CD28 monoclonal antibodies (mAbs) and concanavalin A (ConA) stimulated murine splenocytes proliferation, with IC50 values from (15.25 ± 1.78) μM to (22.58 ± 3.47) μM, disclosing that those compounds might serve as potential lead compounds in the development of new immunosuppressants.
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
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