{"title":"Reducing early pregnancy loss with vitamin D<sub>3</sub>: an analysis of serum 1,25-(OH)D<sub>3</sub> modulation and miscarriage risk.","authors":"Qian Zhao, Liangying Wang, Hongqin Xiang, Luling Qiu","doi":"10.3164/jcbn.24-147","DOIUrl":null,"url":null,"abstract":"<p><p>This case-control study of 124 early-pregnant women found that daily supplementation with 400 IU of vitamin D<sub>3</sub> significantly increased serum 1,25-(OH)D<sub>3</sub> levels and was associated with a lower incidence of threatened miscarriage. The study suggests that vitamin D<sub>3</sub> supplementation could reduce the risk of early miscarriage and improve pregnancy outcomes by modulating immune responses and hormonal stability.</p>","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"76 2","pages":"164-178"},"PeriodicalIF":1.9000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936736/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Biochemistry and Nutrition","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3164/jcbn.24-147","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/10/29 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
引用次数: 0
Abstract
This case-control study of 124 early-pregnant women found that daily supplementation with 400 IU of vitamin D3 significantly increased serum 1,25-(OH)D3 levels and was associated with a lower incidence of threatened miscarriage. The study suggests that vitamin D3 supplementation could reduce the risk of early miscarriage and improve pregnancy outcomes by modulating immune responses and hormonal stability.
期刊介绍：
Journal of Clinical Biochemistry and Nutrition (JCBN) is
an international, interdisciplinary publication encompassing
chemical, biochemical, physiological, pathological, toxicological and medical approaches to research on lipid peroxidation, free radicals, oxidative stress and nutrition. The
Journal welcomes original contributions dealing with all
aspects of clinical biochemistry and clinical nutrition
including both in vitro and in vivo studies.
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