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Helicobacter pylori infection and oxidative stress. 幽门螺杆菌感染和氧化应激。
IF 2 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2024-11-01 Epub Date: 2024-08-02 DOI: 10.3164/jcbn.24-109
Hidekazu Suzuki, Miwa Hirai

Helicobacter pylori (H. pylori) infection promotes the migration of polymorphonuclear leukocytes from the gastric mucosal microcirculation through chemokine induction, leading to the excessive production of ROS. Like eukaryotes, H. pylori possesses superoxide dismutase and catalase, and is resistant to ROS from host polymorphonuclear leukocytes. Oxidants such as monochloramine produced by ROS cause chronic inflammation in the gastric mucosa. H. pylori-derived virulence factor m1-type VacA induces intracellular ROS accumulation and autophagy, which degrades the H. pylori-derived oncoprotein, CagA. In CD44v9-positive gastric cancer stem-like cells, reduced-type glutathione levels increase within the cell because of the cystine transporter on the cell surface, wherein oxidative stress-induced autophagy no longer occurs. As a result, the oncoprotein CagA accumulates in the cells, thus becoming tumorigenic.

幽门螺杆菌(H. pylori)感染会通过趋化因子诱导促进多形核白细胞从胃黏膜微循环中迁移,从而导致产生过多的 ROS。与真核生物一样,幽门螺杆菌也具有超氧化物歧化酶和过氧化氢酶,能抵抗宿主多形核白细胞产生的 ROS。ROS 产生的氧化剂(如一氯胺)会导致胃粘膜慢性炎症。幽门螺杆菌产生的毒力因子 m1 型 VacA 可诱导细胞内 ROS 积累和自噬,从而降解幽门螺杆菌产生的肿瘤蛋白 CagA。在 CD44v9 阳性的胃癌干样细胞中,由于细胞表面的胱氨酸转运体,细胞内还原型谷胱甘肽水平增加,氧化应激诱导的自噬不再发生。结果,癌蛋白 CagA 在细胞内积聚,成为致癌物质。
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引用次数: 0
Prevalence of celiac disease in patients with type 1 diabetes mellitus: a single-center cross-sectional cohort study. 1 型糖尿病患者中乳糜泻的患病率:一项单中心横断面队列研究。
IF 2 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2024-11-01 Epub Date: 2024-06-14 DOI: 10.3164/jcbn.24-39
Yuki Nishimoto, Naoko Hashimoto, Nozomi Kido, Aya Irahara, Takehito Takeuchi, Michinori Takabe, Shunji Ishihara, Yoshikazu Kinoshita, Takeshi Ohara

Type 1 diabetes mellitus (T1DM) may be associated with other autoimmune diseases. Celiac disease (CD), another autoimmune disorder that mainly affects the small intestine, is caused by intolerance to gluten ingestion. CD has a higher prevalence in patients with T1DM than in the general population. However, the prevalence of CD in patients with T1DM in Japan is unknown. This study investigated the prevalence of CD in Japanese patients with T1DM. We included 115 patients with T1DM treated at Hyogo Brain and Heart Center from December 2020 to April 2021. A questionnaire survey about dietary habits and abdominal symptoms was administered, and serum anti-tissue transglutaminase (TTG) antibody titers were determined for all participants. A CD (CD-seropositive) diagnosis was based on TTG levels >10 U/ml. Fifty-eight patients (50.4%) had some abdominal symptoms (such as constipation, diarrhea, and abdominal pain). The average TTG-IgA antibody titer was 0.75 ± 0.49 U/ml and negative (<10 U/ml) in all patients. In conclusion, the prevalence of CD among patients with T1DM at our hospital was 0%. Thus, the prevalence of CD in Japan is low compared to that in other countries, even among patients with T1DM, who are considered to have high comorbidity rates.

1 型糖尿病(T1DM)可能与其他自身免疫性疾病相关。乳糜泻(Celiac disease,CD)是另一种主要影响小肠的自身免疫性疾病,由对麸质摄入不耐受引起。CD 在 T1DM 患者中的发病率高于普通人群。然而,CD 在日本 T1DM 患者中的发病率尚不清楚。本研究调查了 CD 在日本 T1DM 患者中的发病率。我们纳入了2020年12月至2021年4月期间在兵库县脑与心脏中心接受治疗的115名T1DM患者。我们对所有参与者进行了有关饮食习惯和腹部症状的问卷调查,并测定了血清抗组织转谷氨酰胺酶(TTG)抗体滴度。CD(CD-血清阳性)的诊断依据是 TTG 水平>10 U/ml。58 名患者(50.4%)有一些腹部症状(如便秘、腹泻和腹痛)。平均 TTG-IgA 抗体滴度为 0.75 ± 0.49 U/ml,阴性 (
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引用次数: 0
Mechanism of lipid peroxidation of liposomes by cold atmospheric pressure plasma jet irradiation. 冷大气压等离子体射流辐照脂质体的脂质过氧化机理。
IF 2 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2024-11-01 Epub Date: 2024-08-09 DOI: 10.3164/jcbn.24-72
Tokuko Takajo, Koichi Saito, Kazunori Tsuchida, Shunji Kato, Kiyotaka Nakagawa, Akitoshi Okino, Kazunori Anzai

Liposome lipid peroxidation induced by cold atmospheric pressure plasma jet (CAPPJ) irradiation was investigated. The formation of thiobarbituric acid reactive substances (TBARS), an indicator of lipid peroxidation final products, as a function of irradiation was observed. Lipid radicals, peroxidation reaction intermediates generated by CAPPJ irradiation, were confirmed by increased NBD-pen fluorescence intensity. Additionally, lipid peroxidation products, liposomal phosphatidylcholine (PC) isomers, were analyzed by LC-MS/MS. Products specific to singlet oxygen (1O2) oxidation, 16:0/10-hydroperoxy-8E,12Z-octadecanoic acid (10-8E,12Z-HpODE) PC and 16:0/12-9E,13E-HpODE PC, were not detected, but radical oxidation specific products 16:0/13-9E,11E-HpODE PC and 16:0/9-10E,12E-HpODE PC were. This suggests that during CAPPJ irradiation, radicals, rather than 1O2, are the primary reactive species of lipid peroxidation. This is also supported by the β-carotene quenching of 1O2 not suppressing TBARS and lipid radical generation. Also, neither TBARS formation nor lipid radical generation were suppressed by SOD, indicating that the superoxide radical (O2 •-) is not responsible for the lipid peroxidation reaction. As the CAPPJ irradiation of water produces large quantities of hydroxyl radical (OH) and OH scavengers decreased the amount of TBARS produced by CAPPJ irradiation, it is highly plausible that OH is the primary species involved in CAPPJ-induced liposome lipid peroxidation.

研究了冷大气压等离子体射流(CAPPJ)辐照诱导的脂质体脂质过氧化反应。观察了作为脂质过氧化最终产物指标的硫代巴比妥酸活性物质(TBARS)的形成与辐照的函数关系。脂质自由基是 CAPPJ 照射产生的过氧化反应中间产物,通过 NBD-pen 荧光强度的增加得到了证实。此外,还通过 LC-MS/MS 分析了脂质过氧化产物--脂质体磷脂酰胆碱(PC)异构体。未检测到单线态氧(1O2)氧化的特异产物 16:0/10-hydroperoxy-8E,12Z-octadecanoic acid (10-8E,12Z-HpODE) PC 和 16:0/12-9E,13E-HpODE PC,但检测到了自由基氧化的特异产物 16:0/13-9E,11E-HpODE PC 和 16:0/9-10E,12E-HpODE PC。这表明,在 CAPPJ 照射期间,自由基而不是 1O2 是脂质过氧化的主要反应物。β-胡萝卜素对 1O2 的淬灭作用没有抑制 TBARS 和脂质自由基的生成也证明了这一点。此外,SOD 也不能抑制 TBARS 的形成和脂质自由基的生成,这表明超氧自由基(O2--)不是脂质过氧化反应的原因。由于 CAPPJ 照射水会产生大量羟基自由基(-OH),而-OH 清除剂会减少 CAPPJ 照射产生的 TBARS 量,因此,-OH 是参与 CAPPJ 诱导脂质体脂质过氧化反应的主要物种是非常可信的。
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引用次数: 0
Characterized factors of subjects who were first time diagnosed as hyperglycemia more than 126 mg/dl during annual or biannual medical checkups: a case-control study in Japan. 日本一项病例对照研究:年度或半年度体检中首次被诊断为高血糖超过 126 毫克/分升的受试者的特征因素。
IF 2 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2024-11-01 Epub Date: 2024-08-20 DOI: 10.3164/jcbn.24-98
Miwako Minami, Tomohiro Imamura, Ayako Takamori, Hiromu Minagawa, Rina Matsuo, Junko Miyakawa, Kenichi Izumi, Shoichiro Ohta, Kohei Yamanouchi, Nobuya Souta, Kyosuke Yamamoto, Sadatosi Tsuji, Tsukuru Umemura, Keizo Anzai, Yuji Hirai, Kazuma Fujimoto, Takuya Kishi

The present study examined factors in subjects diagnosed with hyperglycemia during periodic medical checkups. In total, 9,324 subjects (males: 4,532, females: 4,792) visited the Takagi Hospital for medical checkups in 2019. Eighty-two subjects (59 males) whose fasting blood glucose exceeded 126 mg/dl for the first time during the annual or biannual follow-up were included. Sex- and age-matched controls were used. Data from cases with hyperglycemia were compared to data from themselves one or two years before hyperglycemia. Body mass index (BMI), waist circumference, fatty liver, and blood pressure were higher in cases than in controls. Fasting blood glucose and hemoglobin A1c were higher in cases. Blood test results indicated that triglyceride, low-density lipoprotein (LDL) cholesterol, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamyl transpeptidase (γ-GTP), were significantly enhanced in cases. Multiple logistic regression analysis revealed that BMI, waist circumference, blood pressure, triglyceride, ALT, and γ-GTP were significant independent risk factors for cases with hyperglycemia. These risk factors were already enhanced in the cases of themselves in one or two years before hyperglycemia. In conclusion, BMI, waist circumference, blood pressure, and fatty liver indicated by ALT and γ-GTP were exacerbated concomitant with hyperglycemia, and increases in these factors preceded hyperglycemia.

本研究调查了在定期体检中被诊断出患有高血糖症的受试者的因素。2019年,共有9324名受试者(男性:4532人,女性:4792人)到高木医院进行体检。其中82名受试者(59名男性)在年度或半年度随访期间空腹血糖首次超过126毫克/分升。同时还使用了性别和年龄匹配的对照组。高血糖病例的数据与高血糖前一、两年的数据进行了比较。病例的体重指数(BMI)、腰围、脂肪肝和血压均高于对照组。病例的空腹血糖和血红蛋白 A1c 均高于对照组。血液检测结果显示,病例的甘油三酯、低密度脂蛋白胆固醇、天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)和γ-谷氨酰转肽酶(γ-GTP)明显升高。多元逻辑回归分析显示,体重指数、腰围、血压、甘油三酯、谷氨酰转肽酶和γ-谷氨酰转肽酶是高血糖病例的重要独立危险因素。这些危险因素在高血糖发生前一、两年的病例中已经有所增强。总之,体重指数(BMI)、腰围、血压以及由谷丙转氨酶(ALT)和γ-谷草转氨酶(γ-GTP)显示的脂肪肝与高血糖同时加剧,而且这些因素的增加先于高血糖。
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引用次数: 0
Effect of cerium oxide on iron metabolism in mice. 氧化铈对小鼠铁代谢的影响
IF 2 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2024-11-01 Epub Date: 2024-08-27 DOI: 10.3164/jcbn.24-38
Yuki Kanome, Shunki Ohtomo, Masaharu Nakatsu, Masahiro Kohno, Koji Fukui

The use of metal nanoparticles such as cerium oxide nanoparticles (nanoceria) in living organisms is attracting increasing attention. We administered nanoceria to chronic kidney disease model rats, including a 5/6 nephrectomy model and adenine administration model rats, and reported high phosphorus adsorption capacity and renal function improvement effects of nanoceria. However, the iron ion concentration in the serum fluctuated significantly after administration. Therefore, we investigated changes in proteins related to iron metabolism following administration of nanoceria to normal mice without chronic kidney disease over different periods of time. Nanoceria were administered to 10-week-old C57BL/6 mice for 4 or 12 weeks. Another group was administrated lanthanum carbonate, which is currently used as a phosphorus adsorbent. The amount of iron in the serum and the concentration of transferrin in the liver were significantly increased following nanoceria administration, and the amount of iron in the liver was significantly decreased. There were no changes in serum hepcidin, ferroportin, cholesterol, or low-density lipoprotein levels. These results indicate that nanoceria administration can affect iron metabolism in mice. Although the detailed mechanism remains unknown, caution is warranted when considering biological utilization in the future.

在生物体内使用金属纳米粒子(如纳米氧化铈)正受到越来越多的关注。我们给慢性肾脏病模型大鼠(包括 5/6 肾切除模型和腺嘌呤给药模型大鼠)注射了纳米铈,结果表明纳米铈具有较高的磷吸附能力和肾功能改善效果。然而,给药后血清中的铁离子浓度波动很大。因此,我们研究了无慢性肾病的正常小鼠在不同时期服用纳米铈后与铁代谢相关的蛋白质的变化。给 10 周大的 C57BL/6 小鼠服用纳米铈 4 周或 12 周。另一组小鼠则服用目前用作磷吸附剂的碳酸镧。给小鼠服用纳米陶瓷后,血清中的铁含量和肝脏中的转铁蛋白浓度明显增加,而肝脏中的铁含量则明显减少。血清降血钙素、铁蛋白、胆固醇和低密度脂蛋白水平没有变化。这些结果表明,服用纳米瓷可以影响小鼠的铁代谢。虽然具体机制尚不清楚,但今后在考虑生物利用时应谨慎。
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引用次数: 0
Innovative novel candy made from a low-solubility amorphous material promotes saliva secretion: a randomized, double-blind, placebo-controlled crossover comparative trial. 由低溶解度无定形材料制成的创新糖果可促进唾液分泌:随机、双盲、安慰剂对照交叉比较试验。
IF 2 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2024-11-01 Epub Date: 2024-08-09 DOI: 10.3164/jcbn.24-103
Shinpei Kawakami, Sadao Mori, Shota Kawasaki, Eisaku Nishimura, Mariko Yoshikawa, Akane Yamaguchi, Yuko Matsui, Toshihiro Kawama, Ichiro Saito

Saliva has antioxidant properties, washes away food residues, and helps maintain the oral environment; thus, decreased saliva secretion can have negative consequences. This study examined how slow-soluble innovative candy, named low-solubility amorphous material, affects oral indices such as saliva secretion and halitosis in a randomized, double-blind, placebo-controlled, crossover comparative study. Twenty-four healthy individuals with low saliva production were given one piece of low-solubility amorphous material or placebo candy and their saliva secretion was measured over 20 min. Before and after participants used the test food, we measured the concentrations of three volatile sulfur compounds involved in halitosis and the secretion rate of secretory immunoglobulin A, and participants completed the Profile of Mood States Second Edition (POMS2) and a visual analog scale (VAS). As a result, saliva secretion increased significantly in low-solubility amorphous material candy condition, compared to placebo candy. Furthermore, changes in the hydrogen sulfide concentration, POMS2 Total Mood Disturbance and Vigor-Activity scores, and oral "moisture" and "refreshed feeling" scores on the VAS were improved more by low-solubility amorphous material candy use than by placebo. Low-solubility amorphous material candy may help improve the oral environment by increasing saliva secretion and reducing halitosis-related substances and may improve mood.

唾液具有抗氧化作用,能洗去食物残渣,有助于维护口腔环境;因此,唾液分泌减少会带来负面影响。本研究通过一项随机、双盲、安慰剂对照、交叉比较研究,考察了名为低溶解度无定形材料的慢溶性创新糖果如何影响唾液分泌和口臭等口腔指标。研究人员给 24 名唾液分泌少的健康人吃了一块低溶解度无定形材料或安慰剂糖果,并在 20 分钟内测量了他们的唾液分泌量。在参与者使用测试食物之前和之后,我们测量了三种与口臭有关的挥发性硫化合物的浓度和分泌性免疫球蛋白 A 的分泌率,参与者还完成了情绪状态档案第二版(POMS2)和视觉模拟量表(VAS)。结果显示,与安慰剂糖果相比,低溶解度无定形物质糖果条件下的唾液分泌量明显增加。此外,使用低溶解度无定形材料糖果比使用安慰剂更能改善硫化氢浓度、POMS2 情绪不安和活力-活动总分以及视觉模拟量表上口腔 "湿润 "和 "清爽感 "得分的变化。低溶解度无定形材料糖果可通过增加唾液分泌和减少口臭相关物质来改善口腔环境,并可改善情绪。
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引用次数: 0
General and sex-specific effects of vitamin D against atrial fibrillation and young-onset ischemic stroke: a Mendelian randomization series. 维生素 D 对心房颤动和年轻缺血性中风的一般影响和性别特异性影响:孟德尔随机系列研究。
IF 2 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2024-11-01 Epub Date: 2024-07-12 DOI: 10.3164/jcbn.24-79
Yap-Hang Chan, Jie V Zhao, C Mary Schooling, Shiu-Lun Au Yeung, Yuen-Kwun Wong, Ka-Wing Au, Clara S Tang, Chloe Yu Yan Cheung, Aimin Xu, Pak-Chung Sham, Tai-Hing Lam, Karen Siu-Ling Lam, Hung-Fat Tse

Whether vitamin D deficiency causes atrial fibrillation and ischemic stroke of young onset was unknown. We derived a Genetic Risk Score for vitamin D from 3,922 subjects in Hong Kong and applied it in an independent sample (n = 1,297) for clinical outcomes. Primary endpoint was a composite of atrial fibrillation and/or ischemic stroke. A second study was performed in the UK Biobank (n = 392,010; 46% men; 14,878 atrial fibrillation and 4,050 ischemic stroke cases, vs 374,102 controls). After 76 ± 46 months, 240 primary endpoints (18.5%) were adjudicated. Higher genetically-predicted vitamin D independently predicted reduced primary endpoint [odds ratio = 0.83 (0.72 to 0.95), p = 0.008]. Mendelian randomization analyses indicated vitamin D was causally protective against the primary endpoint [odds ratio = 0.81 (95% CI: 0.65 to 0.98)]. Independent analyses in the UK Biobank revealed that vitamin D was protective against young-onset ischemic stroke <50 years and atrial fibrillation combined [odds ratio = 0.36 (95% CI 0.14 to 0.94)], with predominant effect amongst men [odds ratio = 0.28 (95% CI 0.09 to 0.91)] compared to women [odds ratio = 0.60 (95% CI: 0.11 to 3.22)]. In conclusion, vitamin D may protect against young-onset ischemic stroke through preventing atrial fibrillation. Investigating the sex-specifc effects of vitamin D deficiency may elucidate sex disparities of atrial fibrillation in the young.

维生素 D 缺乏是否会导致心房颤动和年轻时发病的缺血性中风尚不清楚。我们从香港的 3,922 名受试者中得出了维生素 D 遗传风险评分,并将其应用于独立样本(n = 1,297 人)的临床结果。主要终点是心房颤动和/或缺血性中风的综合结果。第二项研究在英国生物库中进行(n = 392010;46% 男性;14878 例心房颤动和 4050 例缺血性中风病例,对照组 374102 例)。76 ± 46 个月后,对 240 个主要终点(18.5%)进行了判定。较高的基因预测维生素 D 可独立预测主要终点的降低[几率比 = 0.83 (0.72 至 0.95),p = 0.008]。孟德尔随机分析表明,维生素 D 对主要终点具有因果保护作用[几率比 = 0.81(95% CI:0.65 至 0.98)]。英国生物库的独立分析显示,维生素 D 对年轻时发生的缺血性中风具有保护作用
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引用次数: 0
Female patients with end-stage renal failure treated by hemodialysis had a low mortality rate and small patient number compared to male patients: 5-year follow-up study in Japan. 与男性患者相比,接受血液透析治疗的终末期肾衰竭女性患者死亡率低、人数少:日本 5 年随访研究。
IF 2 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2024-11-01 Epub Date: 2024-09-06 DOI: 10.3164/jcbn.24-141
Kuniyasu Takagi, Takuya Kishi, Taku Goto, Kohei Yamanouchi, Kazuhiko Yoshikawa, Tomohiro Imamura, Shiki Nakayama, Keizo Anzai, Yuichiro Akiyoshi, Akira Kitajima, Koji Onozawa, Ayako Takamori, Kazuma Fujimoto

This study aimed to evaluate gender differences of hemodialysis patients in adverse events, gastrointestinal bleeding, and bone fractures during 5 year longitudinal follow-up period in the regional core hospital in Japan. This study included 151 patients with maintenance hemodialysis for end-stage renal failure at Takagi Hospital in December 2017. All the patients, divided into females-group of 61 and males-group of 90. Data were evaluated in the electronic medical record. Multivariate analysis indicated a decrease in diabetes mellitus (odd ratio: 2.3, 95% confidence interval: 1.1-4.8, p = 0.03) and less mortality in those younger than 75 years old (odd ratio: 0.2, 95% confidence interval: 0.1-0.8, p = 0.02) were characterized factors in females. Gastrointestinal bleeding were not different between genders. Bone fractures were high in females (females: 34.4% vs males: 18.9%; p<0.03), whereas the mortality rate of bone fractured patients was markedly high in males (females: 28.6% vs males: 76.5%; p = 0.003) with lower body bone fractures. In conclusion, diabetes mellitus-induced end-stage renal failure was less common in females. The mortality rate during hemodialysis was higher in males less than 75 years old with increased mortality with lower bone fractures.

本研究旨在评估日本地区核心医院5年纵向随访期间血液透析患者在不良事件、消化道出血和骨折方面的性别差异。本研究纳入了2017年12月在高木医院接受终末期肾衰竭维持性血液透析的151名患者。所有患者分为女性组61人和男性组90人。数据通过电子病历进行评估。多变量分析表明,女性糖尿病患者减少(奇数比:2.3,95%置信区间:1.1-4.8,P = 0.03)和75岁以下患者死亡率降低(奇数比:0.2,95%置信区间:0.1-0.8,P = 0.02)是特征性因素。消化道出血在性别上没有差异。女性骨折率较高(女性:34.4%,男性:18.9%;pp = 0.003),全身骨折率较低。总之,糖尿病引发的终末期肾衰竭在女性中较少见。75岁以下男性在血液透析期间的死亡率较高,骨折程度较轻的患者死亡率也较高。
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引用次数: 0
Role of gut microbiota in inflammatory bowel disease pathogenesis. 肠道微生物群在炎症性肠病发病机制中的作用。
IF 2 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2024-11-01 Epub Date: 2024-09-06 DOI: 10.3164/jcbn.24-112
Yuji Naito, Tomohisa Takagi

The role of the gut microbiota, especially bacterial flora, in the pathogenesis of inflammatory bowel disease (IBD) is becoming clearer. Advances in gut microbiota analysis and the use of gnotobiotics models have underscored the importance of gut bacteria and their metabolites in the progression of IBD. Fecal microbiota transplantation has shown promise in clinical trials for ulcerative colitis started as Advanced Medical Care B in Japan, raising expectations for its outcomes. This review explores the gut microbiota's role in IBD, encompassing both current knowledge and future prospects.

肠道微生物群,尤其是细菌群,在炎症性肠病(IBD)发病机制中的作用正变得越来越清晰。肠道微生物群分析的进步和使用生物碱模型突出了肠道细菌及其代谢产物在 IBD 进展过程中的重要性。粪便微生物群移植已在日本先进医疗 B 开始的溃疡性结肠炎临床试验中显示出前景,从而提高了人们对其结果的期望。这篇综述探讨了肠道微生物群在 IBD 中的作用,包括当前的知识和未来的前景。
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引用次数: 0
Effect of omega-3 fatty acids on sleep: a systematic review and meta-analysis of randomized controlled trials. 欧米伽-3 脂肪酸对睡眠的影响:随机对照试验的系统回顾和荟萃分析。
IF 2 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2024-11-01 Epub Date: 2024-08-09 DOI: 10.3164/jcbn.24-36
Kaori Shimizu, Yui Kuramochi, Kohsuke Hayamizu

Omega-3 long-chain polyunsaturated fatty acids (LC-PUFAs) have been reported to improve sleep quality in several studies, but meta-analyses have been inconclusive. We conducted this study to investigate the effects of omega-3 LC-PUFAs on sleep in clinical trials. The study was planned in accordance with the criteria of the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-2020), and was performed by searching PubMed, The Cochrane Library, and Ichushi-web databases. Randomized controlled trials and clinical trials with control groups were included. Finally, eight studies were selected for inclusion in this study. Sleep efficiency was significantly higher in the omega-3 LC-PUFA group than in the control group, while sleep latency and total sleep duration did not differ significantly. Subjectively assessed sleep was significantly improved by omega-3 LC-PUFA, but heterogeneity was so high that a subgroup analysis based on dose of omega-3 supplementation was performed. It showed low heterogeneity and significant improvement in the omega-3 LC-PUFA group compared with the control group. Omega-3 LC-PUFAs have been shown to may improve sleep quality. Further studies are needed to confirm the relationship between omega-3 LC-PUFAs and sleep. The protocol for this review was registered in UMIN000052527.

有多项研究报告称,ω-3 长链多不饱和脂肪酸(LC-PUFAs)可改善睡眠质量,但荟萃分析并无定论。我们开展了这项研究,以调查ω-3 LC-PUFAs在临床试验中对睡眠的影响。本研究根据《系统综述和荟萃分析规程的首选报告项目》(PRISMA-2020)的标准进行规划,并通过检索 PubMed、The Cochrane Library 和 Ichushi-web 数据库进行。随机对照试验和有对照组的临床试验均被纳入其中。最后,本研究选取了八项研究。欧米伽-3 LC-PUFA组的睡眠效率明显高于对照组,而睡眠潜伏期和总睡眠时间则无明显差异。经主观评估,ω-3 LC-PUFA能明显改善睡眠,但异质性很高,因此根据ω-3补充剂的剂量进行了亚组分析。结果显示,与对照组相比,欧米伽-3 LC-PUFA组的异质性较低,且有明显改善。欧米伽-3 LC-PUFA已被证明可改善睡眠质量。要确认ω-3 LC-PUFA与睡眠之间的关系,还需要进一步的研究。本综述的方案已在 UMIN000052527 注册。
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引用次数: 0
期刊
Journal of Clinical Biochemistry and Nutrition
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