Innovations in Snake Venom-Derived Therapeutics: A Systematic Review of Global Patents and Their Pharmacological Applications.

IF 4 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY Toxins Pub Date : 2025-03-14 DOI:10.3390/toxins17030136

Diana Carolina Zona Rubio, Diana Marcela Aragón, Izabel Almeida Alves

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Abstract

Active compounds from natural sources, particularly snake venoms, are crucial for pharmaceutical development despite challenges in drug discovery. Snake venoms, historically used for medicinal purposes, contain bioactive peptides and enzymes that show therapeutic potential for conditions such as arthritis, asthma, cancer, chronic pain, infections and cardiovascular diseases. The objective of this study was to examine pharmacological and biomedical innovations by identifying the key research trends, the most studied snake species, and their therapeutic applications. A systematic review of patents related to snake venoms was conducted using the European Patent Office database, Espacenet, covering 2014 to mid-2024. The search employed the keyword "venom," applying IPC classification A61K38/00, resulting in 31 patents after screening. A PubMed survey on "snake venom derivatives innovations" was conducted to compare the scientific literature volume with the identified patents. This review highlights the therapeutic potential of snake venom-derived products for coagulation disorders, cancer, inflammation, and pain management. Despite challenges in pharmacokinetics and venom variability, advancements in biotechnology offer promise for personalized therapies. The future of snake venom-based treatments appears promising for addressing complex medical conditions.

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蛇毒衍生疗法的创新：全球专利及其药理学应用的系统综述。

尽管药物发现面临挑战，但来自天然来源的活性化合物，特别是蛇毒，对药物开发至关重要。蛇毒历来用于医疗目的，含有生物活性肽和酶，对关节炎、哮喘、癌症、慢性疼痛、感染和心血管疾病等疾病具有治疗潜力。本研究的目的是通过确定主要的研究趋势、研究最多的蛇种及其治疗应用来检查药理学和生物医学的创新。利用欧洲专利局数据库Espacenet，对2014年至2024年中期与蛇毒相关的专利进行了系统审查。检索关键词为“venom”，IPC分类为A61K38/00，经筛选得到31项专利。在PubMed上对“蛇毒衍生物创新”进行了调查，并将科学文献量与已确定的专利进行了比较。这篇综述强调了蛇毒衍生产品在凝血障碍、癌症、炎症和疼痛管理方面的治疗潜力。尽管在药代动力学和毒液变异方面存在挑战，但生物技术的进步为个性化治疗提供了希望。以蛇毒为基础的治疗方法的未来似乎有望解决复杂的医疗状况。

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来源期刊

Toxins TOXICOLOGY-

CiteScore

7.50

自引率

16.70%

发文量

765

审稿时长

16.24 days

期刊介绍： Toxins (ISSN 2072-6651) is an international, peer-reviewed open access journal which provides an advanced forum for studies related to toxins and toxinology. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.