{"title":"Protective Effect of Boric Acid on Oxidative Damage and Cognitive Function in Aging Modeled Rats.","authors":"Emel Serdaroglu Kasikci, Burcu Cevreli, Feride Nihal Sinan, Zeynep Gurdere, Aylin Sonmez, Rumeysa Sonmez","doi":"10.4274/MMJ.galenos.2025.22725","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Aging is a degenerative process. Therefore, the background of our study is to evaluate the effects of boron, one of the important underground resources in Türkiye, on aging and related diseases. This study aimed to assess the antioxidant effect and the cognitive functions of boric acid (BA) in a D-galactose (D-gal)-induced aging model.</p><p><strong>Methods: </strong>Eight male Wistar rats, each 12 weeks old, were split into four groups at random: control, D-gal, BA and D-gal+BA. An experimental aging model was induced by a single subcutaneous injection of D-gal (150 mg/kg/day), and BA (100 mg/kg/day) was administered by oral gavage for 12 weeks. The novel object recognition test (NORT) and Morris water maze (MWM) were used to evaluate the cognitive ability of rats.</p><p><strong>Results: </strong>At the end of the experimental period, glutathione (GSH) and malondialdehyde (MDA) levels were assessed in serum and brain tissue. The treatment of D-gal induced aging rats with BA significantly decreased the MDA level (p<0.05) and increased the GSH level, although the increase was not significant. Moreover, NORT and MWM tests showed that BA significantly improved (p<0.05) cognitive deficits in D-Gal + BA treated rats.</p><p><strong>Conclusions: </strong>BA prevents D-gal-induced memory deficit by decreasing oxidative stress. Hence, BA was a good candidate for addressing age-related neurodegenerative disorders and cognitive function improvements.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"40 1","pages":"18-25"},"PeriodicalIF":1.1000,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974467/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medeniyet medical journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4274/MMJ.galenos.2025.22725","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: Aging is a degenerative process. Therefore, the background of our study is to evaluate the effects of boron, one of the important underground resources in Türkiye, on aging and related diseases. This study aimed to assess the antioxidant effect and the cognitive functions of boric acid (BA) in a D-galactose (D-gal)-induced aging model.
Methods: Eight male Wistar rats, each 12 weeks old, were split into four groups at random: control, D-gal, BA and D-gal+BA. An experimental aging model was induced by a single subcutaneous injection of D-gal (150 mg/kg/day), and BA (100 mg/kg/day) was administered by oral gavage for 12 weeks. The novel object recognition test (NORT) and Morris water maze (MWM) were used to evaluate the cognitive ability of rats.
Results: At the end of the experimental period, glutathione (GSH) and malondialdehyde (MDA) levels were assessed in serum and brain tissue. The treatment of D-gal induced aging rats with BA significantly decreased the MDA level (p<0.05) and increased the GSH level, although the increase was not significant. Moreover, NORT and MWM tests showed that BA significantly improved (p<0.05) cognitive deficits in D-Gal + BA treated rats.
Conclusions: BA prevents D-gal-induced memory deficit by decreasing oxidative stress. Hence, BA was a good candidate for addressing age-related neurodegenerative disorders and cognitive function improvements.
期刊介绍：
The Medeniyet Medical Journal (Medeniyet Med J) is an open access, peer-reviewed, and scientific journal of Istanbul Medeniyet University Faculty of Medicine on various academic disciplines in medicine, which is published in English four times a year, in March, June, September, and December by a group of academics. Medeniyet Medical Journal is the continuation of Göztepe Medical Journal (ISSN: 1300-526X) which was started publishing in 1985. It changed the name as Medeniyet Medical Journal in 2015. Submission and publication are free of charge. No fees are asked from the authors for evaluation or publication process. All published articles are available online in the journal website (www.medeniyetmedicaljournal.org) without any fee. The journal publishes intradisciplinary or interdisciplinary clinical, experimental, and basic researches as well as original case reports, reviews, invited reviews, or letters to the editor, Being published since 1985, the Medeniyet Med J recognizes that the best science should lead to better lives based on the fact that the medicine should serve to the needs of society, and knowledge should transform society. The journal aims to address current issues at both national and international levels, start debates, and exert an influence on decision-makers all over the world by integrating science in everyday life. Medeniyet Med J is committed to serve the public and influence people’s lives in a positive way by making science widely accessible. Believing that the only goal is improving lives, and research has an impact on people’s lives, we select the best research papers in line with this goal.
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