Diagnostic Value of Umbilical Cord Blood Interleukin-6 Level in Premature Infants with Early-Onset Sepsis.

IF 2.1 4区医学 Q2 PEDIATRICS Children-Basel Pub Date : 2025-02-27 DOI:10.3390/children12030301

Jinfang Yuan, Yufeng Wu, Yahui Zhang, Lin Zeng, Jiansuo Zhou, Meihua Piao, Xiaomei Tong, Yuan Wei, Liyan Cui, Tongyan Han

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Abstract

Objective: Early-onset sepsis (EOS) is a serious, grave, and frequently fatal condition in premature infants. This study aimed to assess the diagnostic value of interleukin-6 (IL-6) levels in umbilical cord blood for identifying EOS in preterm infants.

Methods: This prospective cohort study was conducted on preterm infants between May 2019 and April 2021. Based on the diagnostic criteria for EOS, the participants were divided into EOS and non-EOS groups. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic efficacy of cord blood IL-6 levels for EOS.

Results: The levels of IL-6 were significantly higher in the EOS group (n = 10) compared to the non-EOS group (n = 178) [617.5 pg/mL (323.3, 1579.8) vs. 49.7 pg/mL (15.8, 142.8), respectively; p = 0.000]. ROC curve analysis demonstrated that a cutoff value of 250.5 pg/mL for cord blood IL-6 yielded a sensitivity of 90%, specificity of 82%, and area under the curve of 0.876, with a confidence interval of 0.753-0.999, indicating its high accuracy as a diagnostic marker for EOS among preterm infants (p < 0.001).

Conclusions: The detection of IL-6 in the umbilical cord blood offers convenience and exhibits significant diagnostic potential for EOS in preterm infants, thereby providing valuable support for clinical decision-making.

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脐带血白细胞介素-6水平对早发败血症早产儿的诊断价值

目的：早发性脓毒症（EOS）是一种严重的、严重的、经常致命的早产儿疾病。本研究旨在评估脐带血白细胞介素-6 （IL-6）水平对早产儿EOS的诊断价值。方法：对2019年5月至2021年4月期间的早产儿进行前瞻性队列研究。根据EOS的诊断标准，将参与者分为EOS组和非EOS组。采用受试者工作特征（ROC）曲线分析评价脐带血IL-6水平对EOS的诊断效果。结果：EOS组IL-6水平（n = 10）显著高于非EOS组（n = 178）[分别为617.5 pg/mL（323.3, 1579.8）和49.7 pg/mL (15.8, 142.8)；P = 0.000]。ROC曲线分析显示，脐带血IL-6截断值为250.5 pg/mL时，敏感性为90%，特异性为82%，曲线下面积为0.876，置信区间为0.753 ~ 0.999，作为早产儿EOS的诊断指标具有较高的准确性（p < 0.001）。结论：脐带血中IL-6的检测为早产儿EOS的诊断提供了方便，具有重要的诊断潜力，为临床决策提供了有价值的支持。

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来源期刊

Children-Basel PEDIATRICS-

CiteScore

2.70

自引率

16.70%

发文量

1735

审稿时长

6 weeks

期刊介绍： Children is an international, open access journal dedicated to a streamlined, yet scientifically rigorous, dissemination of peer-reviewed science related to childhood health and disease in developed and developing countries. The publication focuses on sharing clinical, epidemiological and translational science relevant to children’s health. Moreover, the primary goals of the publication are to highlight under‑represented pediatric disciplines, to emphasize interdisciplinary research and to disseminate advances in knowledge in global child health. In addition to original research, the journal publishes expert editorials and commentaries, clinical case reports, and insightful communications reflecting the latest developments in pediatric medicine. By publishing meritorious articles as soon as the editorial review process is completed, rather than at predefined intervals, Children also permits rapid open access sharing of new information, allowing us to reach the broadest audience in the most expedient fashion.