Trends and spatial distribution of the burden of vaccine-preventable diseases in children under five in Brazil from 2000 to 2019

IF 4.5 3区医学 Q2 IMMUNOLOGY Vaccine Pub Date : 2025-03-30 DOI:10.1016/j.vaccine.2025.127060

Tércia Moreira Ribeiro da Silva , Ana Carolina Micheletti Gomide Nogueira de Sá , Elton Junio Sady Prates , Guilherme Augusto Veloso , Bárbara Aguiar Carrato , Crizian Saar Gomes , Monsen Naghavi , Deborah Carvalho Malta

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Abstract

Objective

To analyze mortality burden and spatial distribution of vaccine-preventable diseases in children under five in Brazil from 2000 to 2019.

Study design

Ecological study.

Methods

Study using vaccination coverage data from 2000 to 2019 across 5570 Brazilian municipalities, and mortality estimates from the Global Burden of Disease 2019. Spatial analyses were conducted to identify statistically significant clusters (p < 0.05) and spatial autocorrelation.

Results

There was a reduction in mortality from vaccine-preventable diseases in Brazil between 2000 and 2019. The North and Northeast regions showed high mortality rates and lower vaccination coverage compared to other regions.

Conclusions

Infant mortality in Brazil decreased significantly, especially after improvements in vaccination coverage. However, this reduction was not uniform, with the North and Northeast regions showing clusters of high mortality.

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2000年至2019年巴西五岁以下儿童疫苗可预防疾病负担的趋势和空间分布

目的分析2000 - 2019年巴西5岁以下儿童疫苗可预防疾病死亡率负担及空间分布。研究设计生态研究。方法：研究使用2000年至2019年巴西5570个城市的疫苗接种覆盖率数据，以及2019年全球疾病负担的死亡率估计。进行空间分析以确定具有统计学意义的聚类(p <；0.05)和空间自相关。结果2000年至2019年期间，巴西疫苗可预防疾病的死亡率有所下降。与其他地区相比，北部和东北地区的死亡率较高，疫苗接种覆盖率较低。结论巴西的婴儿死亡率显著下降，特别是在疫苗接种覆盖率提高后。然而，这种减少并不均匀，北部和东北部地区显示出高死亡率的聚集性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Vaccine 医学-免疫学

CiteScore

8.70

自引率

5.50%

发文量

992

审稿时长

131 days

期刊介绍： Vaccine is unique in publishing the highest quality science across all disciplines relevant to the field of vaccinology - all original article submissions across basic and clinical research, vaccine manufacturing, history, public policy, behavioral science and ethics, social sciences, safety, and many other related areas are welcomed. The submission categories as given in the Guide for Authors indicate where we receive the most papers. Papers outside these major areas are also welcome and authors are encouraged to contact us with specific questions.