Precision of in Vivo Pesticide Toxicology Research Can Be Promoted by Mass Spectrometry Imaging Technology

Abstract

Pesticides are crucial for agricultural production, but their excessive use has become a significant pollution source, leading to increased pesticide residues in the environment and food and posing a threat to human health. In vivo pesticide toxicology research aims to protect humans with detection technology playing a key role. Spatial information plays a crucial role in in vivo pesticide toxicity research. However, current technologies cannot simultaneously analyze the content and spatial information on pesticides in vivo. Mass spectrometry imaging (MSI) technology can address this limitation by simultaneously analyzing the content and spatial distribution of chemicals in vivo with high sensitivity and efficiency, aiding in the discovery of toxic biomarkers and mechanisms. Nevertheless, the limited application of MSI in vivo pesticide toxicology research hinders the accuracy of such research. Therefore, MSI should be promoted to enhance the accuracy of in vivo pesticide toxicology research.