Vibralactone derivatives isolated from co-cultures of the basidiomycetes Stereum hirsutum and Boreostereum vibrans

IF 4.9 3区化学 Q1 CHEMISTRY, MEDICINAL Natural Products and Bioprospecting Pub Date : 2025-03-31 DOI:10.1007/s13659-025-00505-y

Jinjuan Wei, Zhe-Xi Li, Gao-Ke Peng, Xinyang Li, He-Ping Chen, Ji-Kai Liu

{"title":"Vibralactone derivatives isolated from co-cultures of the basidiomycetes Stereum hirsutum and Boreostereum vibrans","authors":"Jinjuan Wei, Zhe-Xi Li, Gao-Ke Peng, Xinyang Li, He-Ping Chen, Ji-Kai Liu","doi":"10.1007/s13659-025-00505-y","DOIUrl":null,"url":null,"abstract":"<div><p>The basidiomycetes <i>Stereum hirsutum</i> and <i>Boreostereum vibrans</i> are two fungi of the same genus. In this study, chemical investigation on the co-cultures of the two congeneric fungi led to the isolation of eleven new vibralactone derivatives, hirsutavibrins A–K (<b>1</b>–<b>11</b>). The structures of <b>1</b>–<b>11</b> were elucidated by extensive NMR and HRESIMS spectroscopic analysis, and computational methods. Hirsutavibrins A (<b>1</b>) and B (<b>2</b>) showed weak cytotoxicity against the human lung cancer cell line A549. Hirsutavibrin D (<b>4</b>) showed moderate anti-nitric oxide activity in murine monocytic RAW 264.7 macrophages. This work not only expands the members of vibralactone derivatives with variable configurations but also opens a new avenue for fungal co-culturing study between congeneric fungi.</p><h3>Graphical Abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"15 1","pages":""},"PeriodicalIF":4.9000,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-025-00505-y.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Products and Bioprospecting","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s13659-025-00505-y","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}

引用次数: 0

Abstract

The basidiomycetes Stereum hirsutum and Boreostereum vibrans are two fungi of the same genus. In this study, chemical investigation on the co-cultures of the two congeneric fungi led to the isolation of eleven new vibralactone derivatives, hirsutavibrins A–K (1–11). The structures of 1–11 were elucidated by extensive NMR and HRESIMS spectroscopic analysis, and computational methods. Hirsutavibrins A (1) and B (2) showed weak cytotoxicity against the human lung cancer cell line A549. Hirsutavibrin D (4) showed moderate anti-nitric oxide activity in murine monocytic RAW 264.7 macrophages. This work not only expands the members of vibralactone derivatives with variable configurations but also opens a new avenue for fungal co-culturing study between congeneric fungi.

Graphical Abstract

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

从担子菌hirsutum和Boreostereum vibrans共培养中分离的振动内酯衍生物

担子菌hirsutum和Boreostereum vibrans是同一属的两种真菌。本研究对这两种同属真菌的共培养进行化学研究，分离出11个新的振动内酯衍生物hirsutavibrins A-K（1-11）。1-11的结构被广泛的核磁共振和hresms光谱分析和计算方法阐明。Hirsutavibrins A(1)和B(2)对人肺癌细胞系A549表现出较弱的细胞毒性。Hirsutavibrin D(4)在小鼠单核细胞RAW 264.7巨噬细胞中显示出中等的抗一氧化氮活性。这项工作不仅扩大了振动内酯衍生物的可变构型成员，而且为同属真菌之间的共培养研究开辟了新的途径。图形抽象

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Natural Products and Bioprospecting CHEMISTRY, MEDICINAL-

CiteScore

8.30

自引率

2.10%

发文量

审稿时长

13 weeks

期刊介绍： Natural Products and Bioprospecting serves as an international forum for essential research on natural products and focuses on, but is not limited to, the following aspects: Natural products: isolation and structure elucidation Natural products: synthesis Biological evaluation of biologically active natural products Bioorganic and medicinal chemistry Biosynthesis and microbiological transformation Fermentation and plant tissue cultures Bioprospecting of natural products from natural resources All research articles published in this journal have undergone rigorous peer review. In addition to original research articles, Natural Products and Bioprospecting publishes reviews and short communications, aiming to rapidly disseminate the research results of timely interest, and comprehensive reviews of emerging topics in all the areas of natural products. It is also an open access journal, which provides free access to its articles to anyone, anywhere.