The role of yes-associated protein in nasal inflammatory diseases

Abstract

Yes-associated protein (YAP), a pivotal protein of the Hippo signaling pathway, plays a crucial role in regulating cell proliferation and differentiation. Emerging evidence highlights its significance in respiratory inflammatory disorders, including chronic rhinosinusitis, allergic rhinitis. This review delves into the impact of YAP on individuals affected by these ailments, with a specific focus on the role it plays in nasal mucosal epithelial cells. We further explore the interplay between YAP and the inflammatory mediators, outlining the pathological mechanisms through which it contributes to tissue restructuring in these contexts. Despite advancements, gaps persist in understanding YAP's broader role in clinical applications. Future research directions are proposed in this article to bridge these knowledge gaps.