The organ distribution of [3H]endotoxin following partial hepatectomy.

M Shirai, J Shiga, G Yoshimura, I Fukuda, S Kanegasaki, W Mori
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Abstract

3H-labeled endotoxin was intravenously injected into Wistar rats 24 hours following 70% hepatectomy and also into the normal rats. They were sacrificed 12 hours, 24 hours or 5 days after the injection. Microscopical autoradiography was performed on the rats' organs. The distribution of endotoxin in the organs was investigated by quantitatively measuring their radioactivity. Endotoxin was taken up mainly by Kupffer cells of the liver in all the groups. Endotoxin was observed also in macrophages of the spleen and the lung in all the groups. The amount of endotoxin per 1 g organ weight of the hepatectomized rat was significantly smaller in the liver, and significantly larger in the spleen, lung and blood (per 1 ml) than that of the control groups early after hepatectomy. These differences of the organ accumulation of endotoxin between groups diminished 5 days later. Deficient tolerance of the liver to endotoxin at the peak phase of regeneration following partial hepatectomy was suggested.

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肝部分切除术后[3H]内毒素的器官分布。
在Wistar大鼠肝切除70%后24小时静脉注射3h标记内毒素,正常大鼠也注射3h标记内毒素。分别于注射后12小时、24小时和5天处死。对大鼠各脏器进行显微放射自显影。通过定量测定内毒素的放射性,研究了内毒素在脏器中的分布。内毒素主要由肝库普弗氏细胞吸收。各组小鼠脾、肺巨噬细胞均可见内毒素。肝切除大鼠每1 g脏器重量的内毒素含量在肝切除后早期显著低于对照组,而在脾、肺和血液中的内毒素含量(每1 ml)显著高于对照组。5 d后,各组间内毒素积累的差异逐渐减小。在肝部分切除后再生的高峰阶段,肝脏对内毒素的耐受性不足。
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