Mechanistic insights and therapeutic approaches in tic disorders: The distinctive role of ethnomedicine and modern medical interventions

Abstract

Tic disorders (TDs) are a class of neurodevelopmental disorders that have received considerable scientific attention. The genesis of TDs is increasingly understood as a complex interplay of neurobiological, genetic, and immunological factors. Animal model studies have elucidated the pathophysiology of TDs, paving the way for innovative therapeutic approaches. This review provides a comprehensive analysis of the etiologic basis, experimental framework, and treatment strategies for TDs, highlighting the contributions of ethnomedicine and modern medicine. Our synthesis aims to deepen the understanding of the disease and spur the development of superior treatments. In addition, we present new insights and hypotheses for the future management of TDs, emphasizing the need for continued research into their etiology and progression, as well as the pursuit of more effective therapies. We advocate personalized, holistic care strategies that focus on symptom relief and improving patients' quality of life. Overall, this review provides a critical compendium for TD researchers and practitioners to help navigate the complexities of these disorders.