Serum Biomarkers and Their Clinical Correlates in Traumatic Trigeminal Neuropathy: A Pilot Study.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Oral diseases Pub Date : 2025-08-01 Epub Date: 2025-03-31 DOI:10.1111/odi.15322

Hye-Kyoung Kim, Insoon Chang, Sung-Hoon Lee

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Abstract

Objectives: This study aims to investigate the serum biomarker levels in patients with painful post-traumatic trigeminal neuropathy (PPTTN) and explore the associations between these biomarkers and the clinical and psychological characteristics of the patients.

Materials and methods: A total of 32 patients with PPTTN were included. Serum levels of various cytokines and neurotrophic factors were measured. Patients were assessed for clinical and psychological characteristics, including pain severity, pain interference, numbness severity, and symptom duration as well as psychological factors using validated questionnaires.

Results: No significant differences in serum biomarker levels were found based on age, sex, pain severity, pain interference, or type of injured nerve after adjusting multiple comparisons. Significant differences were observed in interleukin-8 (IL-8) and brain-derived neurotrophic factor (BDNF) levels based on symptom duration, with higher levels in patients whose symptoms lasted for more than 6 months. Spearman correlation analysis revealed strong relationships between clinical and psychological variables. Pain outcomes were more strongly associated with psychological factors than with serum biomarkers.

Conclusion: IL-8 and BDNF may be biomarkers for disease progression in PPTTN based on symptom duration, with pain outcomes more related to psychological factors rather than serum biomarker levels, highlighting the need for psychological support in management.

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创伤性三叉神经病变的血清生物标志物及其临床相关性：一项初步研究。

目的：研究疼痛性创伤后三叉神经病变（PPTTN）患者的血清生物标志物水平，并探讨这些生物标志物与患者临床和心理特征的关系。材料与方法：共纳入32例PPTTN患者。测定血清中各种细胞因子和神经营养因子的水平。采用有效问卷评估患者的临床和心理特征，包括疼痛严重程度、疼痛干扰、麻木严重程度、症状持续时间以及心理因素。结果：调整多重比较后，血清生物标志物水平未发现基于年龄、性别、疼痛严重程度、疼痛干扰或损伤神经类型的显著差异。白细胞介素-8 （IL-8）和脑源性神经营养因子（BDNF）水平根据症状持续时间有显著差异，症状持续6个月以上的患者水平较高。Spearman相关分析显示临床变量和心理变量之间有很强的相关性。与血清生物标志物相比，疼痛结果与心理因素的相关性更强。结论：基于症状持续时间，IL-8和BDNF可能是PPTTN疾病进展的生物标志物，疼痛结局与心理因素而非血清生物标志物水平更相关，强调在治疗中需要心理支持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.