Strategies and Research Progress of Surface Antithrombotic Polymer Coating Under Inflammatory Conditions

Abstract

Cardiovascular diseases (CVD) is the leading causes of mortality globally. Various blood-contact medical devices, by applying anticoagulant coatings on the material surface. Utilizing various anticoagulants and enhancing the lubricity of medical device surfaces can effectively reduce short-term thrombotic risks. However, thrombosis in long-term or medium-to-long-term implanted devices remains a significant challenge. Current evidence suggests that during prolonged implantation, immune rejection of the device and its matrix, along with chronic inflammation induced by the disease, are key contributors to late-stage thrombosis. Therefore, modulating inflammation under pathological conditions is considered crucial for achieving long-term antithrombotic objectives. This review summarizes several representative antithrombotic coatings strategies based on anti-inflammatory and introduces some of the research contributions in this area.