Impact of Obesity on the Surgical Outcomes After Laparoscopic Liver Resection for Liver Tumors: A Meta-Analysis.

IF 2.4 4区医学 Q3 NUTRITION & DIETETICS Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2025-04-02 DOI:10.1080/01635581.2025.2486153

Faying Liu, Yang Zou, Qing Chen, Tao Chen, He Xiao, Tingbing Xie, Lihe Zheng, Qi Ruan, Wang Liu

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Abstract

Objective: The impact of obesity on the surgical outcomes in patients after laparoscopic liver resection (LLR) is unclear. We aimed at conducting a meta-analysis to evaluate the associations between overweight and obesity and major surgical outcomes after LLR for liver tumors.

Methods: We searched PubMed, Cochrane Library, Embase, and Web of Science databases for eligible studies. Odds ratios (ORs) and mean differences (MDs) with 95% confidence intervals (CIs) were calculated.

Results: Eight studies were included, with a total of 7,580 patients. Findings indicated that, relative to individuals of normal weight, those in the higher body mass index (BMI) category (overweight and obese) had prolonged operation time (MD, 15.46 mins), increased blood loss (MD, 39.40 mL), overall complications (OR 1.20), conversion (OR 1.41), and surgical site infection (SSI) (OR 1.77). In addition, subgroup analysis showed that although overweight did not increase the risk of overall postoperative complications and SSI, obesity significantly increased the risk of overall postoperative complications, SSI, and conversion to laparotomy.

Conclusion: In conclusion, higher BMI, especially obesity, is closely associated with higher risk of morbidity after laparoscopic liver resection.

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肥胖对腹腔镜肝肿瘤切除术后手术结果的影响：一项荟萃分析

目的：目前尚不清楚肥胖对腹腔镜肝切除术（LLR）患者手术效果的影响。我们旨在进行一项荟萃分析，以评估超重和肥胖与肝肿瘤LLR后主要手术结果之间的关系。方法：我们检索PubMed、Cochrane Library、Embase和Web of Science数据库寻找符合条件的研究。计算95%置信区间（ci）的优势比（ORs）和平均差异（MDs）。结果：纳入8项研究，共7580例患者。结果显示，相对于体重正常的个体，体重指数（BMI）较高类别（超重和肥胖）的患者手术时间延长（MD, 15.46 min），出血量增加（MD, 39.40 mL），总并发症（OR 1.20），转换（OR 1.41）和手术部位感染（SSI）（OR 1.77）。此外，亚组分析显示，虽然超重没有增加术后总并发症和SSI的风险，但肥胖显著增加了术后总并发症、SSI和转开腹手术的风险。结论：综上所述，高BMI，尤其是肥胖，与腹腔镜肝切除术后较高的发病风险密切相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition and Cancer-An International Journal 医学-营养学

CiteScore

5.80

自引率

3.40%

发文量

172

审稿时长

3 months

期刊介绍： This timely publication reports and reviews current findings on the effects of nutrition on the etiology, therapy, and prevention of cancer. Etiological issues include clinical and experimental research in nutrition, carcinogenesis, epidemiology, biochemistry, and molecular biology. Coverage of therapy focuses on research in clinical nutrition and oncology, dietetics, and bioengineering. Prevention approaches include public health recommendations, preventative medicine, behavior modification, education, functional foods, and agricultural and food production policies.