Carboxymethyl cellulose/hydroxyapatite/Fe3O4 bio-nanocomposite hydrogel beads: an efficient oral pH-responsive carrier for doxorubicin delivery

IF 2.5 4区化学 Q2 Engineering Chemical Papers Pub Date : 2025-02-17 DOI:10.1007/s11696-025-03944-6

Rauf Foroutan, Ali Mohammadzadeh, Reza Mohammadi, Siamak Javanbakht

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Abstract

In this study, an oral pH-responsive carrier, carboxymethyl cellulose/hydroxyapatite/Fe₃O₄ bio-nanocomposite hydrogel beads (CMC/HAp/Fe₃O₄), was prepared to control the release profile of anticancer doxorubicin (DOX) drug. Surface morphology of the CMC/HAp/Fe₃O₄ bio-nanocomposite hydrogel beads was studied using different techniques. The magnetic measurement studies revealed a good superparamagnetic behavior for the prepared bio-nanocomposite hydrogel beads with a saturation magnetization of 28.73 emu/g. The pH-responsive drug release was verified by in vitro release test and showed a lower release at acidic media (pH 1.2) and a higher release under alkaline conditions (i.e., pH 7.4 and 6.8). Besides, the MTT assay revealed that the DOX-loaded CMC/HAp/Fe₃O₄ has the desired cytotoxicity against SW480 cells. According to the results, the prepared bio-nanocomposite hydrogel beads have a high potential for being used as biomaterials.

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羧甲基纤维素/羟基磷灰石/Fe3O4生物纳米复合水凝胶珠：一种有效的口服阿霉素ph响应载体

本研究制备了一种口服ph响应载体羧甲基纤维素/羟基磷灰石/Fe3O4生物纳米复合水凝胶珠（CMC/HAp/Fe3O4），以控制抗癌药物阿霉素（DOX）的释放谱。采用不同的工艺研究了CMC/HAp/Fe3O4生物纳米复合水凝胶珠的表面形貌。磁测量结果表明，制备的生物纳米复合水凝胶珠具有良好的超顺磁性，饱和磁化强度为28.73 emu/g。体外释放试验验证了药物的pH响应性释放，在酸性介质（pH 1.2）下释放较低，在碱性条件（pH 7.4和6.8）下释放较高。此外，MTT实验显示，负载dox的CMC/HAp/Fe3O4对SW480细胞具有预期的细胞毒性。结果表明，制备的生物纳米复合水凝胶珠具有很高的生物材料应用潜力。

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来源期刊

Chemical Papers Chemical Engineering-General Chemical Engineering

CiteScore

3.30

自引率

4.50%

发文量

590

期刊介绍： Chemical Papers is a peer-reviewed, international journal devoted to basic and applied chemical research. It has a broad scope covering the chemical sciences, but favors interdisciplinary research and studies that bring chemistry together with other disciplines.