Nikolai Tsankov MD, PhD, DrSci , Ivan Grozdev MD, PhD
{"title":"Tuberculosis and psoriasis: Is there a link between them?","authors":"Nikolai Tsankov MD, PhD, DrSci , Ivan Grozdev MD, PhD","doi":"10.1016/j.clindermatol.2025.03.017","DOIUrl":null,"url":null,"abstract":"<div><div>Tuberculosis (TB) is a socially significant disease caused by <em>Mycobacterium tuberculosis</em>. Latent TB represents a state of continuous immune response to stimulation by <em>M tuberculosis</em> and its antigens without the clinical signs of TB. Biologic agents could trigger latent TB into active TB, which is the reason why psoriasis patients should be screened for latent TB before initiating biologic therapy. The data of the efficacy of rifampicin in severe psoriasis patients treated for their coexisting active TB, along with the data of psoriasis remission after rifampicin therapy in subjects with no active TB, raise the question of whether there is a link between psoriasis and TB. There is also a question of the efficacy of the date from rifampicin, when used for treating patients having severe psoriasis as well as coexisting active TB. Is there a link between psoriasis and TB?</div></div>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":"43 3","pages":"Pages 386-388"},"PeriodicalIF":2.2000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinics in dermatology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0738081X25001117","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/31 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Tuberculosis (TB) is a socially significant disease caused by Mycobacterium tuberculosis. Latent TB represents a state of continuous immune response to stimulation by M tuberculosis and its antigens without the clinical signs of TB. Biologic agents could trigger latent TB into active TB, which is the reason why psoriasis patients should be screened for latent TB before initiating biologic therapy. The data of the efficacy of rifampicin in severe psoriasis patients treated for their coexisting active TB, along with the data of psoriasis remission after rifampicin therapy in subjects with no active TB, raise the question of whether there is a link between psoriasis and TB. There is also a question of the efficacy of the date from rifampicin, when used for treating patients having severe psoriasis as well as coexisting active TB. Is there a link between psoriasis and TB?
期刊介绍：
Clinics in Dermatology brings you the most practical and comprehensive information on the treatment and care of skin disorders. Each issue features a Guest Editor and is devoted to a single timely topic relating to clinical dermatology.
Clinics in Dermatology provides information that is...
• Clinically oriented -- from evaluation to treatment, Clinics in Dermatology covers what is most relevant to you in your practice.
• Authoritative -- world-renowned experts in the field assure the high-quality and currency of each issue by reporting on their areas of expertise.
• Well-illustrated -- each issue is complete with photos, drawings and diagrams to illustrate points and demonstrate techniques.
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