Vasodilator activity of methanol extract obtained from Crataegus rosei leaves and the chemical characterization of its main constituents.

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED Natural Product Research Pub Date : 2025-04-03 DOI:10.1080/14786419.2025.2486334

Diana López-Fitz, Eloy Rodríguez-de-León, Rebeca Rodríguez-Martínez, César Ibarra-Alvarado, Moustapha Bah, Mahinda Martínez, Leticia García-Aguilar

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Abstract

Persistent arterial hypertension (AHT) plays a very important role in the development of cardiovascular diseases (CVD). The present study assessed the vasodilator activities of the methanol extract (ME) and its fractions obtained from leaves of a Mexican Crataegus rosei plant. The fat- and tannin-free ME fraction (FTFME) produced the most potent vasodilator effect [EC₅₀ 8.253 (4.672 to 14.58 μg/mL)], that was 6.7-fold higher than that of the ME [EC₅₀ = 55.49 (29.78 to 68.69) μg/mL], which was similar to that of ACh used as a positive control. This effect was dependent on the nitric oxide/cGMP pathway. Six triterpene acids (ursolic, oleanolic, euscaphic, maslinic, corosolic, and alphitolic) were identified as the main constituents of this fraction. In contrast to the commercially available Crataegus extracts, these compounds must be the most suitable chemical and pharmacological markers for this methanol extract in research into obtaining a standardised antihypertensive extract.

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山楂叶甲醇提取物的血管扩张活性及其主要成分的化学性质。

持续性动脉高血压（AHT）在心血管疾病（CVD）的发展中起着非常重要的作用。本研究评估了甲醇提取物（ME）及其组分的血管舒张活性从墨西哥山楂玫瑰植物的叶子获得。不含脂肪和单宁的代谢能组分（FTFME）的血管舒张作用最强[EC50 = 8.253 (4.672 ~ 14.58 μg/mL)]，是代谢能组分[EC50 = 55.49 (29.78 ~ 68.69) μg/mL]的6.7倍，与作为阳性对照的乙酰氨基酚（ACh）相似。这种作用依赖于一氧化氮/cGMP途径。六种三萜酸（熊果酸、齐墩果酸、熊果酸、山茱萸酸、鹿角果酸和α酚酸）被鉴定为该组分的主要成分。与市售的山楂提取物相比，这些化合物必须是甲醇提取物中最合适的化学和药理学标记物，以获得标准化的抗高血压提取物。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.