Multi-voxel pattern analysis for developmental cognitive neuroscientists

Abstract

The current prevailing approaches to analyzing task fMRI data in developmental cognitive neuroscience are brain connectivity and mass univariate task-based analyses, used either in isolation or as part of a broader analytic framework (e.g., BWAS). While these are powerful tools, it is somewhat surprising that multi-voxel pattern analysis (MVPA) is not more common in developmental cognitive neuroscience given its enhanced ability to both probe neural population codes and greater sensitivity relative to the mass univariate approach. Omitting MVPA methods might represent a missed opportunity to leverage a suite of tools that are uniquely poised to reveal mechanisms underlying brain development. The goal of this review is to spur awareness and adoption of MVPA in developmental cognitive neuroscience by providing a practical introduction to foundational MVPA concepts. We begin by defining MVPA and explain why examining multi-voxel patterns of brain activity can aid in understanding the developing human brain. We then survey four different types of MVPA: Decoding, representational similarity analysis (RSA), pattern expression, and voxel-wise encoding models. Each variant of MVPA is presented with a conceptual overview of the method followed by practical considerations and subvariants thereof. We go on to highlight the types of developmental questions that can be answered by MPVA, discuss practical matters in MVPA implementation germane to developmental cognitive neuroscientists, and make recommendations for integrating MVPA with the existing analytic ecosystem in the field.