{"title":"Amide bond formation between substances located in two immiscible liquid phases without phase-transfer catalyst","authors":"Xiao-Fei Gao , Wei Xiao , Meng Qiu , Zhi-Gang Cheng , Xiang-Zhao Chen","doi":"10.1016/j.ijms.2025.117443","DOIUrl":null,"url":null,"abstract":"<div><div>Effectively amide bond construction between substances located in two immiscible liquids is a key point in the covalent-combination of the two parts with totally different characters. Herein, we demonstrated that aminolysis reactions between substances located in two immiscible solutions can be promoted in microdroplets without phase transfer catalyst, leading to amide bond formation products. Furthermore, in the biphasic reaction of microdroplets, size of the hydrophobic group and length of the alkyl chain in an activated ester may also affect a lot on the aminolysis reaction. This result will provide us a further insight on interfacial microdroplet reaction between substances located in two immiscible liquid phases and a new approach for ligation of two substances with totally different properties.</div></div>","PeriodicalId":338,"journal":{"name":"International Journal of Mass Spectrometry","volume":"512 ","pages":"Article 117443"},"PeriodicalIF":1.7000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Mass Spectrometry","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1387380625000478","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/30 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"PHYSICS, ATOMIC, MOLECULAR & CHEMICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Effectively amide bond construction between substances located in two immiscible liquids is a key point in the covalent-combination of the two parts with totally different characters. Herein, we demonstrated that aminolysis reactions between substances located in two immiscible solutions can be promoted in microdroplets without phase transfer catalyst, leading to amide bond formation products. Furthermore, in the biphasic reaction of microdroplets, size of the hydrophobic group and length of the alkyl chain in an activated ester may also affect a lot on the aminolysis reaction. This result will provide us a further insight on interfacial microdroplet reaction between substances located in two immiscible liquid phases and a new approach for ligation of two substances with totally different properties.
期刊介绍：
The journal invites papers that advance the field of mass spectrometry by exploring fundamental aspects of ion processes using both the experimental and theoretical approaches, developing new instrumentation and experimental strategies for chemical analysis using mass spectrometry, developing new computational strategies for data interpretation and integration, reporting new applications of mass spectrometry and hyphenated techniques in biology, chemistry, geology, and physics.
Papers, in which standard mass spectrometry techniques are used for analysis will not be considered.
IJMS publishes full-length articles, short communications, reviews, and feature articles including young scientist features.
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