{"title":"Scaling a foundational protein language model to 100 billion parameters","authors":"","doi":"10.1038/s41592-025-02637-y","DOIUrl":null,"url":null,"abstract":"xTrimoPGLM, a protein language model scaled to 100 billion parameters, showcased scaling behavior to excel in various protein-related tasks. This development advances protein understanding and design, and contributes to the evolving landscape of comprehensive models designed to serve as a base for various specialized tasks (foundation models) in protein science.","PeriodicalId":18981,"journal":{"name":"Nature Methods","volume":"22 5","pages":"908-909"},"PeriodicalIF":32.1000,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Methods","FirstCategoryId":"99","ListUrlMain":"https://www.nature.com/articles/s41592-025-02637-y","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
引用次数: 0
Abstract
xTrimoPGLM, a protein language model scaled to 100 billion parameters, showcased scaling behavior to excel in various protein-related tasks. This development advances protein understanding and design, and contributes to the evolving landscape of comprehensive models designed to serve as a base for various specialized tasks (foundation models) in protein science.
期刊介绍：
Nature Methods is a monthly journal that focuses on publishing innovative methods and substantial enhancements to fundamental life sciences research techniques. Geared towards a diverse, interdisciplinary readership of researchers in academia and industry engaged in laboratory work, the journal offers new tools for research and emphasizes the immediate practical significance of the featured work. It publishes primary research papers and reviews recent technical and methodological advancements, with a particular interest in primary methods papers relevant to the biological and biomedical sciences. This includes methods rooted in chemistry with practical applications for studying biological problems.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
