{"title":"Spotting multifaced actions of magnesium on NMDA receptors.","authors":"Adam Fekete, Lu-Yang Wang","doi":"10.1016/j.neuron.2025.03.011","DOIUrl":null,"url":null,"abstract":"<p><p>NMDARs act as coincidence detectors for synaptic plasticity by activity-dependent relief of Mg<sup>2+</sup> pore block. In this issue of Neuron, Huang et al. solved the structure of NMDARs to enlighten the fascinating actions of Mg<sup>2+</sup> beyond its pore binding.<sup>1</sup>.</p>","PeriodicalId":19313,"journal":{"name":"Neuron","volume":"113 7","pages":"963-965"},"PeriodicalIF":15.0000,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuron","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.neuron.2025.03.011","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
NMDARs act as coincidence detectors for synaptic plasticity by activity-dependent relief of Mg2+ pore block. In this issue of Neuron, Huang et al. solved the structure of NMDARs to enlighten the fascinating actions of Mg2+ beyond its pore binding.1.
期刊介绍：
Established as a highly influential journal in neuroscience, Neuron is widely relied upon in the field. The editors adopt interdisciplinary strategies, integrating biophysical, cellular, developmental, and molecular approaches alongside a systems approach to sensory, motor, and higher-order cognitive functions. Serving as a premier intellectual forum, Neuron holds a prominent position in the entire neuroscience community.
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