{"title":"A case of fatal poisoning caused by a combination of tramadol and benzodiazepines","authors":"Sella Takei , Hiroshi Kinoshita , Mitsuru Kumihashi , Mostofa Jamal , Tadayoshi Yamashita , Etsuko Tanaka , Sachiko Kawahara , Hiroko Abe , Kunihiko Tsutsui , Takehiko Murase","doi":"10.1016/j.legalmed.2025.102619","DOIUrl":null,"url":null,"abstract":"<div><div>Tramadol exerts analgesic effects by acting as an agonist of μ-opioid receptor and by inhibiting reuptake of serotonin and noradrenaline. Here we report an autopsy case of a woman in her thirties, with multiple drugs detected. Based on the autopsy findings and toxicological examination results, we concluded the death was attributed to the ingestion of tramadol and benzodiazepines, which was thought to have primarily resulted from CNS depression. Co-ingested drugs should be considered when evaluating toxicity.</div></div>","PeriodicalId":49913,"journal":{"name":"Legal Medicine","volume":"74 ","pages":"Article 102619"},"PeriodicalIF":1.4000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Legal Medicine","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1344622325000537","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, LEGAL","Score":null,"Total":0}
引用次数: 0
Abstract
Tramadol exerts analgesic effects by acting as an agonist of μ-opioid receptor and by inhibiting reuptake of serotonin and noradrenaline. Here we report an autopsy case of a woman in her thirties, with multiple drugs detected. Based on the autopsy findings and toxicological examination results, we concluded the death was attributed to the ingestion of tramadol and benzodiazepines, which was thought to have primarily resulted from CNS depression. Co-ingested drugs should be considered when evaluating toxicity.
期刊介绍：
Legal Medicine provides an international forum for the publication of original articles, reviews and correspondence on subjects that cover practical and theoretical areas of interest relating to the wide range of legal medicine.
Subjects covered include forensic pathology, toxicology, odontology, anthropology, criminalistics, immunochemistry, hemogenetics and forensic aspects of biological science with emphasis on DNA analysis and molecular biology. Submissions dealing with medicolegal problems such as malpractice, insurance, child abuse or ethics in medical practice are also acceptable.
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