Effect of Ligand Length on Antibacterial Activity of Ultrasmall Gold Nanoparticles

IF 8.7 1区化学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY ACS Materials Letters Pub Date : 2025-03-22 DOI:10.1021/acsmaterialslett.4c02608

Zehui Yao, Shasha Zhang*, Zijun Zhang, Quan Wan, Taolei Sun and Guanbin Gao*,

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Abstract

Three different length ligands (3/6/11-aminopropylthiol hydrochloride (APT/AHT/AUT)) were modified onto the surface of ultrasmall (d < 3 nm) gold nanoparticles (AuNPs) to investigate the ligand length on their antibacterial performance. Compared with the medium-chain AHT-AuNPs, both the short-chain APT-AuNPs and the long-chain AUT-AuNPs exhibited better antibacterial activity against Escherichia coli and Staphylococcus aureus. Antibacterial mechanistic investigations revealed that the adsorption efficiency of AHT-AuNPs on bacterial membranes was significantly lower compared with APT-AuNPs and AUT-AuNPs. This resulted in reduced membrane disruption, decreased ATP depletion, and diminished ROS generation by AHT-AuNPs relative to APT-AuNPs and AUT-AuNPs, ultimately leading to a lower antibacterial efficacy of AHT-AuNPs compared with APT-AuNPs and AUT-AuNPs. This study offers novel insights into the correlation between the structural features of ultrasmall AuNPs and their antibacterial efficacy, serving as a valuable reference for optimizing the ligand chain length in the development of high-performance nanoantibacterial materials.

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配体长度对超小金纳米颗粒抗菌活性的影响

将三种不同长度的配体（3/6/11-氨基丙基硫醇盐化物（APT/AHT/AUT））修饰在超小(d <；3 nm)的金纳米颗粒（AuNPs）研究配体长度对其抗菌性能的影响。与中链AHT-AuNPs相比，短链AHT-AuNPs和长链AHT-AuNPs对大肠杆菌和金黄色葡萄球菌均表现出更好的抗菌活性。抑菌机理研究表明，与APT-AuNPs和AUT-AuNPs相比，AHT-AuNPs在细菌膜上的吸附效率显著降低。这导致相对于APT-AuNPs和AUT-AuNPs， AHT-AuNPs的膜破坏减少，ATP耗损减少，ROS生成减少，最终导致AHT-AuNPs的抗菌效果低于APT-AuNPs和AUT-AuNPs。本研究为超小AuNPs的结构特征与抗菌效果之间的关系提供了新的见解，为开发高性能纳米抗菌材料优化配体链长度提供了有价值的参考。

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来源期刊

ACS Materials Letters MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

14.60

自引率

3.50%

发文量

261

期刊介绍： ACS Materials Letters is a journal that publishes high-quality and urgent papers at the forefront of fundamental and applied research in the field of materials science. It aims to bridge the gap between materials and other disciplines such as chemistry, engineering, and biology. The journal encourages multidisciplinary and innovative research that addresses global challenges. Papers submitted to ACS Materials Letters should clearly demonstrate the need for rapid disclosure of key results. The journal is interested in various areas including the design, synthesis, characterization, and evaluation of emerging materials, understanding the relationships between structure, property, and performance, as well as developing materials for applications in energy, environment, biomedical, electronics, and catalysis. The journal has a 2-year impact factor of 11.4 and is dedicated to publishing transformative materials research with fast processing times. The editors and staff of ACS Materials Letters actively participate in major scientific conferences and engage closely with readers and authors. The journal also maintains an active presence on social media to provide authors with greater visibility.