Artificial Human Blood Vessels for Tissue Engineering

IF 8.7 1区 化学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY ACS Materials Letters Pub Date : 2025-03-27 DOI:10.1021/acsmaterialslett.5c00038
Yi Zhang, Lina Lin, Mengying Niu, Feika Bian*, Weijian Wang* and Yan Zu*, 
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Abstract

Vasculature occupies a crucial position in maintaining human life. However, repairing vascular injuries remains an essential challenge in clinical treatment. In recent years, vascular tissue engineering has undergone rapid progress. Compared with traditional autogenous vessel grafting, artificial blood vessels have diverse advantages, benefiting from excellent biocompatibility, mechanical properties, and controllable structures. This review focuses on the recent development of artificial engineered blood vessels to offer a systematic review of fabrication and applications of this technique. Initially, preparation materials of artificial vessels are introduced. In addition, manufacturing methods of artificial vessels are discussed, including casting, spinning, 3D printing, and microfluidics. Then, the applications in vascular replacement therapy, vascular access for hemodialysis, and peripheral arterial disease are depicted. Finally, the recent challenges and prospects of this technique are described. It is hoped that this systematic review provides valuable information to relevant researchers and encourages advancements in the creation of tissue-engineered blood vessels.

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用于组织工程的人造血管
脉管系统在维持人类生命中占有至关重要的地位。然而,血管损伤的修复仍然是临床治疗中的一个重要挑战。近年来,血管组织工程研究取得了长足的进展。与传统的自体血管移植相比,人工血管具有多种优点,具有良好的生物相容性、力学性能和结构可控性。本文综述了近年来人造工程血管的研究进展,对人工工程血管的制备和应用进行了系统的综述。首先介绍了人工血管的制备材料。此外,还讨论了人工容器的制造方法,包括铸造、纺丝、3D打印和微流体。然后,描述了在血管替代治疗,血液透析血管通路和外周动脉疾病中的应用。最后,对该技术面临的挑战和前景进行了展望。希望这一系统综述能为相关研究人员提供有价值的信息,并鼓励组织工程血管的创造取得进展。
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来源期刊
ACS Materials Letters
ACS Materials Letters MATERIALS SCIENCE, MULTIDISCIPLINARY-
CiteScore
14.60
自引率
3.50%
发文量
261
期刊介绍: ACS Materials Letters is a journal that publishes high-quality and urgent papers at the forefront of fundamental and applied research in the field of materials science. It aims to bridge the gap between materials and other disciplines such as chemistry, engineering, and biology. The journal encourages multidisciplinary and innovative research that addresses global challenges. Papers submitted to ACS Materials Letters should clearly demonstrate the need for rapid disclosure of key results. The journal is interested in various areas including the design, synthesis, characterization, and evaluation of emerging materials, understanding the relationships between structure, property, and performance, as well as developing materials for applications in energy, environment, biomedical, electronics, and catalysis. The journal has a 2-year impact factor of 11.4 and is dedicated to publishing transformative materials research with fast processing times. The editors and staff of ACS Materials Letters actively participate in major scientific conferences and engage closely with readers and authors. The journal also maintains an active presence on social media to provide authors with greater visibility.
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